Catalyst-Substrate Effects on Biocompatible SABRE Hyperpolarization

Anand Manoharan; Peter J. Rayner; Marianna Fekete; Wissam Iali; Philip Norcott; V. Hugh Perry; Simon B. Duckett

doi:10.1002/cphc.201800915

Catalyst-Substrate Effects on Biocompatible SABRE Hyperpolarization

Anand Manoharan
, Peter J. Rayner
, Marianna Fekete
, Wissam Iali
, Philip Norcott
, V. Hugh Perry
, Simon B. Duckett^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The hyperpolarization technique, Signal Amplification by Reversible Exchange (SABRE), has the potential to improve clinical diagnosis by making molecular magnetic resonance imaging in vivo a reality. Essential to this goal is the ability to produce a biocompatible bolus for administration. We seek here to determine how the identity of the catalyst and substrate affects the cytotoxicity by in vitro study, in addition to reporting how the use of biocompatible solvent mixtures influence the polarization transfer efficiency. By illustrating this across five catalysts and 8 substrates, we are able to identify routes to produce a bolus with minimal cytotoxic effects.

Original language	English
Pages (from-to)	285-294
Number of pages	10
Journal	ChemPhysChem
Volume	20
Issue number	2
DOIs	https://doi.org/10.1002/cphc.201800915
State	Published - 21 Jan 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

SABRE
biocompatibility
biomolecules
cytotoxicity
hyperpolarization

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Physical and Theoretical Chemistry

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10.1002/cphc.201800915

Cite this

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title = "Catalyst-Substrate Effects on Biocompatible SABRE Hyperpolarization",

abstract = "The hyperpolarization technique, Signal Amplification by Reversible Exchange (SABRE), has the potential to improve clinical diagnosis by making molecular magnetic resonance imaging in vivo a reality. Essential to this goal is the ability to produce a biocompatible bolus for administration. We seek here to determine how the identity of the catalyst and substrate affects the cytotoxicity by in vitro study, in addition to reporting how the use of biocompatible solvent mixtures influence the polarization transfer efficiency. By illustrating this across five catalysts and 8 substrates, we are able to identify routes to produce a bolus with minimal cytotoxic effects.",

keywords = "SABRE, biocompatibility, biomolecules, cytotoxicity, hyperpolarization",

author = "Anand Manoharan and Rayner, \{Peter J.\} and Marianna Fekete and Wissam Iali and Philip Norcott and \{Hugh Perry\}, V. and Duckett, \{Simon B.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

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doi = "10.1002/cphc.201800915",

language = "English",

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AU - Manoharan, Anand

AU - Rayner, Peter J.

AU - Fekete, Marianna

AU - Iali, Wissam

AU - Norcott, Philip

AU - Hugh Perry, V.

AU - Duckett, Simon B.

PY - 2019/1/21

Y1 - 2019/1/21

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AB - The hyperpolarization technique, Signal Amplification by Reversible Exchange (SABRE), has the potential to improve clinical diagnosis by making molecular magnetic resonance imaging in vivo a reality. Essential to this goal is the ability to produce a biocompatible bolus for administration. We seek here to determine how the identity of the catalyst and substrate affects the cytotoxicity by in vitro study, in addition to reporting how the use of biocompatible solvent mixtures influence the polarization transfer efficiency. By illustrating this across five catalysts and 8 substrates, we are able to identify routes to produce a bolus with minimal cytotoxic effects.

KW - SABRE

KW - biocompatibility

KW - biomolecules

KW - cytotoxicity

KW - hyperpolarization

UR - https://www.scopus.com/pages/publications/85057322150

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M3 - Article

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AN - SCOPUS:85057322150

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VL - 20

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JO - ChemPhysChem

JF - ChemPhysChem

IS - 2

ER -

Catalyst-Substrate Effects on Biocompatible SABRE Hyperpolarization

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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