Candida antarctica lipase B-catalyzed synthesis of acetamides using [BMIm(PF6)] as a reaction medium

Kishor P. Dhake; Ziyauddin S. Qureshi; Rekha S. Singhal; Bhalchandra M. Bhanage

doi:10.1016/j.tetlet.2009.03.170

Candida antarctica lipase B-catalyzed synthesis of acetamides using [BMIm(PF₆)] as a reaction medium

Kishor P. Dhake, Ziyauddin S. Qureshi, Rekha S. Singhal, Bhalchandra M. Bhanage^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

An efficient protocol has been developed for synthesis of acetamides using Candida antarctica lipase B (CaL B) in [BMIm(PF₆)] as a greener reaction medium. The reaction is applicable to a wide variety of aliphatic esters/acetic acid and amines providing excellent yields of corresponding acetamide. The catalyst exhibits remarkable activity and is reusable for up to four consecutive cycles.

Original language	English
Pages (from-to)	2811-2814
Number of pages	4
Journal	Tetrahedron Letters
Volume	50
Issue number	23
DOIs	https://doi.org/10.1016/j.tetlet.2009.03.170
State	Published - 10 Jun 2009
Externally published	Yes

Bibliographical note

Funding Information:
The author (K.P.D.) is greatly thankful to the UGC-SAP (University Grant Commission, India) for providing him the fellowship during this research work.

Keywords

Acetamide-synthesis
Amidation
Candida antarctica lipase B (CaL B)
Enzymatic synthesis
Ionic liquids

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tetlet.2009.03.170

Cite this

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title = "Candida antarctica lipase B-catalyzed synthesis of acetamides using [BMIm(PF6)] as a reaction medium",

abstract = "An efficient protocol has been developed for synthesis of acetamides using Candida antarctica lipase B (CaL B) in [BMIm(PF6)] as a greener reaction medium. The reaction is applicable to a wide variety of aliphatic esters/acetic acid and amines providing excellent yields of corresponding acetamide. The catalyst exhibits remarkable activity and is reusable for up to four consecutive cycles.",

keywords = "Acetamide-synthesis, Amidation, Candida antarctica lipase B (CaL B), Enzymatic synthesis, Ionic liquids",

author = "Dhake, {Kishor P.} and Qureshi, {Ziyauddin S.} and Singhal, {Rekha S.} and Bhanage, {Bhalchandra M.}",

note = "Funding Information: The author (K.P.D.) is greatly thankful to the UGC-SAP (University Grant Commission, India) for providing him the fellowship during this research work. ",

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doi = "10.1016/j.tetlet.2009.03.170",

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AU - Dhake, Kishor P.

AU - Qureshi, Ziyauddin S.

AU - Singhal, Rekha S.

AU - Bhanage, Bhalchandra M.

N1 - Funding Information: The author (K.P.D.) is greatly thankful to the UGC-SAP (University Grant Commission, India) for providing him the fellowship during this research work.

PY - 2009/6/10

Y1 - 2009/6/10

N2 - An efficient protocol has been developed for synthesis of acetamides using Candida antarctica lipase B (CaL B) in [BMIm(PF6)] as a greener reaction medium. The reaction is applicable to a wide variety of aliphatic esters/acetic acid and amines providing excellent yields of corresponding acetamide. The catalyst exhibits remarkable activity and is reusable for up to four consecutive cycles.

AB - An efficient protocol has been developed for synthesis of acetamides using Candida antarctica lipase B (CaL B) in [BMIm(PF6)] as a greener reaction medium. The reaction is applicable to a wide variety of aliphatic esters/acetic acid and amines providing excellent yields of corresponding acetamide. The catalyst exhibits remarkable activity and is reusable for up to four consecutive cycles.

KW - Acetamide-synthesis

KW - Amidation

KW - Candida antarctica lipase B (CaL B)

KW - Enzymatic synthesis

KW - Ionic liquids

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