Calcium-doped organosilicate nanoparticles as gene delivery vehicles for bone cells

The potential application of Ca-doped organosilicate nanoparticles for gene delivery has been demonstrated by researchers. Osteoblast-nanoparticle interactions were used to design Ca-doped nanoparticles that had transfected bone cells without inducing cytoxicity. Normal bone possesses a substantial capacity for regenerating itself following a fracture, while orthopedic medicine on the other hand lacks an effective treatment for many fractures that are cured with difficulty. Existing technologies to treat these fractures include autografts, allografts, synthetic bone grafts, and the addition of growth factors to synthetic grafts for accelerating bone regeneration.The results suggested that the Ca-SiO₂ nanoparticles-DNA complexes can be useful towards bone regeneration applications, which provided the basis for designing an in vivo study for understanding the clinical utility of the nanoparticles.