Bovine reticulum derived extracellular matrix (b-REM) for reconstruction of full thickness skin wounds in rats

Anwarul Hasan; Naveen Kumar; Aswathy Gopinathan; Kiranjeet Singh; A. K. Sharma; V. Remya; Sameer Shrivastava; Sonal; S. K. Maiti; D. B. Mondal; K. P. Singh

doi:10.1016/j.wndm.2016.02.003

Bovine reticulum derived extracellular matrix (b-REM) for reconstruction of full thickness skin wounds in rats

Anwarul Hasan, Naveen Kumar^*, Aswathy Gopinathan, Kiranjeet Singh, A. K. Sharma, V. Remya, Sameer Shrivastava, Sonal, S. K. Maiti, D. B. Mondal, K. P. Singh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Thirty six clinically healthy adult Wistar rats of either sex were used in the study and randomly divided into three groups having twelve animals in each group. Under general anesthesia, a full-thickness skin wound (20 × 20 mm²) was created on the dorsum of each rat. The defect in group I was kept as open wound and was taken as control. In group II, the defect was repaired with commercially available collagen sheet (b-CS). In group III, the defect was repaired with reticulum derived extracellular matrix of bovine origin (b-REM). Healing was evaluated on the basis of wound contraction, gross, haematological, immunological and histopathological observations. On critical analysis of the observed parameters it was found that b-REM has healing potential and shown better healing response than commercially available collagen sheet to reconstruct full thickness skin wounds in rats.

Original language	English
Pages (from-to)	19-31
Number of pages	13
Journal	Wound Medicine
Volume	12
DOIs	https://doi.org/10.1016/j.wndm.2016.02.003
State	Published - 1 Mar 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier GmbH.

Keywords

Bovine collagen sheet (b-CS)
Bovine reticulum derived extracellular matrix (b-REM)
Rats
Wound healing

ASJC Scopus subject areas

Surgery

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10.1016/j.wndm.2016.02.003

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@article{daf7e5e8a2b0488dbe9a21f8d9030b39,

title = "Bovine reticulum derived extracellular matrix (b-REM) for reconstruction of full thickness skin wounds in rats",

abstract = "Thirty six clinically healthy adult Wistar rats of either sex were used in the study and randomly divided into three groups having twelve animals in each group. Under general anesthesia, a full-thickness skin wound (20 × 20 mm2) was created on the dorsum of each rat. The defect in group I was kept as open wound and was taken as control. In group II, the defect was repaired with commercially available collagen sheet (b-CS). In group III, the defect was repaired with reticulum derived extracellular matrix of bovine origin (b-REM). Healing was evaluated on the basis of wound contraction, gross, haematological, immunological and histopathological observations. On critical analysis of the observed parameters it was found that b-REM has healing potential and shown better healing response than commercially available collagen sheet to reconstruct full thickness skin wounds in rats.",

keywords = "Bovine collagen sheet (b-CS), Bovine reticulum derived extracellular matrix (b-REM), Rats, Wound healing",

author = "Anwarul Hasan and Naveen Kumar and Aswathy Gopinathan and Kiranjeet Singh and Sharma, \{A. K.\} and V. Remya and Sameer Shrivastava and Sonal and Maiti, \{S. K.\} and Mondal, \{D. B.\} and Singh, \{K. P.\}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier GmbH.",

year = "2016",

month = mar,

day = "1",

doi = "10.1016/j.wndm.2016.02.003",

language = "English",

volume = "12",

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journal = "Wound Medicine",

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TY - JOUR

T1 - Bovine reticulum derived extracellular matrix (b-REM) for reconstruction of full thickness skin wounds in rats

AU - Hasan, Anwarul

AU - Kumar, Naveen

AU - Gopinathan, Aswathy

AU - Singh, Kiranjeet

AU - Sharma, A. K.

AU - Remya, V.

AU - Shrivastava, Sameer

AU - Sonal,

AU - Maiti, S. K.

AU - Mondal, D. B.

AU - Singh, K. P.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Thirty six clinically healthy adult Wistar rats of either sex were used in the study and randomly divided into three groups having twelve animals in each group. Under general anesthesia, a full-thickness skin wound (20 × 20 mm2) was created on the dorsum of each rat. The defect in group I was kept as open wound and was taken as control. In group II, the defect was repaired with commercially available collagen sheet (b-CS). In group III, the defect was repaired with reticulum derived extracellular matrix of bovine origin (b-REM). Healing was evaluated on the basis of wound contraction, gross, haematological, immunological and histopathological observations. On critical analysis of the observed parameters it was found that b-REM has healing potential and shown better healing response than commercially available collagen sheet to reconstruct full thickness skin wounds in rats.

AB - Thirty six clinically healthy adult Wistar rats of either sex were used in the study and randomly divided into three groups having twelve animals in each group. Under general anesthesia, a full-thickness skin wound (20 × 20 mm2) was created on the dorsum of each rat. The defect in group I was kept as open wound and was taken as control. In group II, the defect was repaired with commercially available collagen sheet (b-CS). In group III, the defect was repaired with reticulum derived extracellular matrix of bovine origin (b-REM). Healing was evaluated on the basis of wound contraction, gross, haematological, immunological and histopathological observations. On critical analysis of the observed parameters it was found that b-REM has healing potential and shown better healing response than commercially available collagen sheet to reconstruct full thickness skin wounds in rats.

KW - Bovine collagen sheet (b-CS)

KW - Bovine reticulum derived extracellular matrix (b-REM)

KW - Rats

KW - Wound healing

UR - https://www.scopus.com/pages/publications/84959200282

U2 - 10.1016/j.wndm.2016.02.003

DO - 10.1016/j.wndm.2016.02.003

M3 - Article

AN - SCOPUS:84959200282

SN - 2213-9095

VL - 12

SP - 19

EP - 31

JO - Wound Medicine

JF - Wound Medicine

ER -

Bovine reticulum derived extracellular matrix (b-REM) for reconstruction of full thickness skin wounds in rats

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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