Biotechnological improvements of cold- adapted enzymes: Commercialization via an integrated approach

Khawar Sohail Siddiqui*, Ahsan Mushir Shemsi, Gea Guerriero, Tahria Najnin, Taha, Haluk Ertan

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations


Cold-adapted (psychrophilic) enzymes have intrinsically high activities at the expense of low stabilities due to their flexible structures. Their higher thermolability limits their applications under numerous industrial conditions that require the process to be carried out at higher temperatures for efficient catalysis. Therefore, for effective utilization, cold-adapted enzymes need to be improved in such a way that enhances their stability with an increase or retention of their activity. This chapter discusses the thermodynamic aspects of improvement of catalytic properties and presents a unified strategy that aims at simultaneously improving the activity and stability of cold-adapted enzymes by employing not a single but a combination of approaches that include genetic and chemical.

Original languageEnglish
Title of host publicationPsychrophiles
Subtitle of host publicationFrom Biodiversity to Biotechnology: Second Edition
PublisherSpringer International Publishing
Number of pages36
ISBN (Electronic)9783319570570
ISBN (Print)9783319570563
StatePublished - 1 Jul 2017

ASJC Scopus subject areas

  • General Immunology and Microbiology
  • General Biochemistry, Genetics and Molecular Biology
  • General Physics and Astronomy


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