Bifunctional Fe3O4-Ag heterodimer nanoparticles for two-photon fluorescence imaging and magnetic manipulation

Jiang Jiang; Hongwei Gu; Huilin Shao; Eamonn Devlin; Georgia C. Papaefthymiou; Jackie Y. Ying

doi:10.1002/adma.200800498

Bifunctional Fe₃O₄-Ag heterodimer nanoparticles for two-photon fluorescence imaging and magnetic manipulation

Jiang Jiang^*
, Hongwei Gu
, Huilin Shao
, Eamonn Devlin
, Georgia C. Papaefthymiou
, Jackie Y. Ying

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

266 Scopus citations

Abstract

The development of noble metal nanocrystal-based two-photon fluorescence indicator combined with magnetic nanoparticles as a new class of bifunctional nanocomposites was reported. Magnetic nanoparticles were first synthesized by thermal decomposition of iron-oleate complex. Heterodimer nanoparticles were then formed by reducing Ag in the presence of the pre-synthesized magnetite seed nanoparticles. Ag reduction was found to take at least 30 minutes under similar reaction conditions. The Fe₃O₄-Ag heterodimer nanoparticles were superparamagnetic with a blocking temperature of 225 K and a magnetization value of 66 emu/g Fe₃O₄ at an applied field of 50 kOe at 6 K. After uptake of the heterodimer nanoparticles by macrophage cells, strong two-photon fluorescence was observed upon excitation by femtosecond infrared laser pulses of 900 nm. No significant autofluorescence was observed under similar experimental conditions or even higher excitation laser power.

Original language	English
Pages (from-to)	4403-4407
Number of pages	5
Journal	Advanced Materials
Volume	20
Issue number	23
DOIs	https://doi.org/10.1002/adma.200800498
State	Published - 2 Dec 2008
Externally published	Yes

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

Access to Document

10.1002/adma.200800498

Cite this

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title = "Bifunctional Fe3O4-Ag heterodimer nanoparticles for two-photon fluorescence imaging and magnetic manipulation",

abstract = "The development of noble metal nanocrystal-based two-photon fluorescence indicator combined with magnetic nanoparticles as a new class of bifunctional nanocomposites was reported. Magnetic nanoparticles were first synthesized by thermal decomposition of iron-oleate complex. Heterodimer nanoparticles were then formed by reducing Ag in the presence of the pre-synthesized magnetite seed nanoparticles. Ag reduction was found to take at least 30 minutes under similar reaction conditions. The Fe3O4-Ag heterodimer nanoparticles were superparamagnetic with a blocking temperature of 225 K and a magnetization value of 66 emu/g Fe3O4 at an applied field of 50 kOe at 6 K. After uptake of the heterodimer nanoparticles by macrophage cells, strong two-photon fluorescence was observed upon excitation by femtosecond infrared laser pulses of 900 nm. No significant autofluorescence was observed under similar experimental conditions or even higher excitation laser power.",

author = "Jiang Jiang and Hongwei Gu and Huilin Shao and Eamonn Devlin and Papaefthymiou, \{Georgia C.\} and Ying, \{Jackie Y.\}",

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T1 - Bifunctional Fe3O4-Ag heterodimer nanoparticles for two-photon fluorescence imaging and magnetic manipulation

AU - Jiang, Jiang

AU - Gu, Hongwei

AU - Shao, Huilin

AU - Devlin, Eamonn

AU - Papaefthymiou, Georgia C.

AU - Ying, Jackie Y.

PY - 2008/12/2

Y1 - 2008/12/2

N2 - The development of noble metal nanocrystal-based two-photon fluorescence indicator combined with magnetic nanoparticles as a new class of bifunctional nanocomposites was reported. Magnetic nanoparticles were first synthesized by thermal decomposition of iron-oleate complex. Heterodimer nanoparticles were then formed by reducing Ag in the presence of the pre-synthesized magnetite seed nanoparticles. Ag reduction was found to take at least 30 minutes under similar reaction conditions. The Fe3O4-Ag heterodimer nanoparticles were superparamagnetic with a blocking temperature of 225 K and a magnetization value of 66 emu/g Fe3O4 at an applied field of 50 kOe at 6 K. After uptake of the heterodimer nanoparticles by macrophage cells, strong two-photon fluorescence was observed upon excitation by femtosecond infrared laser pulses of 900 nm. No significant autofluorescence was observed under similar experimental conditions or even higher excitation laser power.

AB - The development of noble metal nanocrystal-based two-photon fluorescence indicator combined with magnetic nanoparticles as a new class of bifunctional nanocomposites was reported. Magnetic nanoparticles were first synthesized by thermal decomposition of iron-oleate complex. Heterodimer nanoparticles were then formed by reducing Ag in the presence of the pre-synthesized magnetite seed nanoparticles. Ag reduction was found to take at least 30 minutes under similar reaction conditions. The Fe3O4-Ag heterodimer nanoparticles were superparamagnetic with a blocking temperature of 225 K and a magnetization value of 66 emu/g Fe3O4 at an applied field of 50 kOe at 6 K. After uptake of the heterodimer nanoparticles by macrophage cells, strong two-photon fluorescence was observed upon excitation by femtosecond infrared laser pulses of 900 nm. No significant autofluorescence was observed under similar experimental conditions or even higher excitation laser power.

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