TY - JOUR
T1 - Baseline in vitro activities of the antimalarials pyronaridine and methylene blue against Plasmodium falciparum isolates from Kenya
AU - Okombo, John
AU - Kiara, Steven M.
AU - Mwai, Leah
AU - Pole, Lewa
AU - Ohuma, Eric
AU - Ochola, Lynette Isabella
AU - Nzila, Alexis
PY - 2012/2
Y1 - 2012/2
N2 - We have analyzed the in vitro activities of pyronaridine and methylene blue against 59 Plasmodium falciparum isolates from Kenya in association with polymorphisms in Pfcrt (codon 76), Pfmdr1 (codon 86), and Pfnhe (full sequence). The median inhibitory concentrations that kill 50% of parasites were 13.5 and 3.3 nM for pyronaridine and methylene blue, respectively. Their activities were not associated with polymorphisms in these genes. The drugs' high in vitro activities indicate that they would be efficacious against Kenyan isolates in vivo.
AB - We have analyzed the in vitro activities of pyronaridine and methylene blue against 59 Plasmodium falciparum isolates from Kenya in association with polymorphisms in Pfcrt (codon 76), Pfmdr1 (codon 86), and Pfnhe (full sequence). The median inhibitory concentrations that kill 50% of parasites were 13.5 and 3.3 nM for pyronaridine and methylene blue, respectively. Their activities were not associated with polymorphisms in these genes. The drugs' high in vitro activities indicate that they would be efficacious against Kenyan isolates in vivo.
UR - https://www.scopus.com/pages/publications/84856068996
U2 - 10.1128/AAC.05454-11
DO - 10.1128/AAC.05454-11
M3 - Article
C2 - 22123687
AN - SCOPUS:84856068996
SN - 0066-4804
VL - 56
SP - 1105
EP - 1107
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 2
ER -
