Base-Promoted α-Alkylation of Arylacetonitriles with Alcohols

Bivas Chandra Roy; Istikhar A. Ansari; Sk Abdus Samim; Sabuj Kundu

doi:10.1002/asia.201900285

Base-Promoted α-Alkylation of Arylacetonitriles with Alcohols

Bivas Chandra Roy
, Istikhar A. Ansari
, Sk Abdus Samim
, Sabuj Kundu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

A practical method to synthesize α-alkylated arylacetonitriles from arylacetonitriles and alcohols without using any expensive transition metal complexes is demonstrated here. Following this base-catalysed sustainable procedure, various arylacetonitriles were successfully alkylated with different alcohols. The practical applicability of this protocol was extended by one-pot synthesis of important carboxylic acid derivatives.

Original language	English
Pages (from-to)	2215-2219
Number of pages	5
Journal	Chemistry - An Asian Journal
Volume	14
Issue number	13
DOIs	https://doi.org/10.1002/asia.201900285
State	Published - 1 Jul 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

C-C bond formation
alkylation
arylacetonitriles
base catalysis
transition-metal-free

ASJC Scopus subject areas

General Chemistry
Biochemistry
Organic Chemistry

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10.1002/asia.201900285

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title = "Base-Promoted α-Alkylation of Arylacetonitriles with Alcohols",

abstract = "A practical method to synthesize α-alkylated arylacetonitriles from arylacetonitriles and alcohols without using any expensive transition metal complexes is demonstrated here. Following this base-catalysed sustainable procedure, various arylacetonitriles were successfully alkylated with different alcohols. The practical applicability of this protocol was extended by one-pot synthesis of important carboxylic acid derivatives.",

keywords = "C-C bond formation, alkylation, arylacetonitriles, base catalysis, transition-metal-free",

author = "Roy, \{Bivas Chandra\} and Ansari, \{Istikhar A.\} and Samim, \{Sk Abdus\} and Sabuj Kundu",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2019",

month = jul,

day = "1",

doi = "10.1002/asia.201900285",

language = "English",

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journal = "Chemistry - An Asian Journal",

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TY - JOUR

T1 - Base-Promoted α-Alkylation of Arylacetonitriles with Alcohols

AU - Roy, Bivas Chandra

AU - Ansari, Istikhar A.

AU - Samim, Sk Abdus

AU - Kundu, Sabuj

PY - 2019/7/1

Y1 - 2019/7/1

N2 - A practical method to synthesize α-alkylated arylacetonitriles from arylacetonitriles and alcohols without using any expensive transition metal complexes is demonstrated here. Following this base-catalysed sustainable procedure, various arylacetonitriles were successfully alkylated with different alcohols. The practical applicability of this protocol was extended by one-pot synthesis of important carboxylic acid derivatives.

AB - A practical method to synthesize α-alkylated arylacetonitriles from arylacetonitriles and alcohols without using any expensive transition metal complexes is demonstrated here. Following this base-catalysed sustainable procedure, various arylacetonitriles were successfully alkylated with different alcohols. The practical applicability of this protocol was extended by one-pot synthesis of important carboxylic acid derivatives.

KW - C-C bond formation

KW - alkylation

KW - arylacetonitriles

KW - base catalysis

KW - transition-metal-free

UR - https://www.scopus.com/pages/publications/85066900738

U2 - 10.1002/asia.201900285

DO - 10.1002/asia.201900285

M3 - Article

C2 - 31046180

AN - SCOPUS:85066900738

SN - 1861-4728

VL - 14

SP - 2215

EP - 2219

JO - Chemistry - An Asian Journal

JF - Chemistry - An Asian Journal

IS - 13

ER -

Base-Promoted α-Alkylation of Arylacetonitriles with Alcohols

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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