Bactericidal Action and Industrial Dye Degradation of Graphene Oxide and Polyacrylic Acid-Doped SnO2 Quantum Dots: In Silico Molecular Docking Study

Saira Riaz, Muhammad Ikram*, Sadia Naz, Anum Shahzadi, Walid Nabgan*, Anwar Ul-Hamid, Ali Haider, Junaid Haider, Ali Al-Shanini*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The present work demonstrates the systematic incorporation of different concentrations of graphene oxide (GO) into a fixed amount of polyacrylic acid (PAA)-doped SnO2 quantum dots (QDs) through a co-precipitation approach. The research aimed to evaluate the catalytic and antibacterial actions of GO/PAA-SnO2 QDs. Moreover, optical properties, surface morphologies, crystal structures, elemental compositions, and d-spacings of prepared QDs were examined. X-ray diffraction patterns revealed the tetragonal configuration of SnO2, and the crystallinity of QDs was suppressed upon dopants verified by the SAED patterns. Electronic spectra identified the blue shift by incorporating GO and PAA led to a reduction in band gap energy. Fourier transform infrared spectra showed the existence of rotational and vibrational modes associated with the functional groups during the synthesis process. A drastic increase in the catalytic efficacy of QDs was observed in the neutral medium by including dopants, indicating that GO/PAA-SnO2 is a promising catalyst. GO/PAA-SnO2 showed strong bactericidal efficacy against Escherichia coli (E. coli) at higher GO concentrations. Molecular docking studies predicted the given nanocomposites, i.e., SnO2, PAA-SnO2, and GO/PAA-SnO2, as potential inhibitors of beta-lactamaseE. coli and DNA gyraseE.

Original languageEnglish
Pages (from-to)5808-5819
Number of pages12
JournalACS Omega
Volume8
Issue number6
DOIs
StatePublished - 14 Feb 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors. Published by American Chemical Society.

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

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