Assay of nimodipine - an anti hypertensive drug, in bulk form and pharmaceutical formulations by cathodic adsorptive stripping voltammetry

Vinod K. Gupta; Rajeev Jain; Milan M. Antonijevic; Hadi Khani; M. N. Siddiqui; Ashish Dwivedi; Ritesh Mishra; Shilpi Agarwal

doi:10.1016/s1452-3981(23)14973-x

Assay of nimodipine - an anti hypertensive drug, in bulk form and pharmaceutical formulations by cathodic adsorptive stripping voltammetry

Vinod K. Gupta^*
, Rajeev Jain
, Milan M. Antonijevic
, Hadi Khani
, M. N. Siddiqui
, Ashish Dwivedi
, Ritesh Mishra
, Shilpi Agarwal

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Adsorpitive Stripping square-wave voltammetry (SWV) and differential-pulse voltammetry (DPV) methods were developed, evaluated, and compared for the assay of nimodipine in pharmaceutical formulations. The proposed method allows determination of nimodipine in linear concentration range 2 × 10^-5 to 2 × 10^-6 mol L^-1. The Limit of detection (LOD) and limit of quantification (LOQ) were noticed to be 7.11 ng/mL and 32.92 ng/mL respectively. The procedure was applied to the assay of the drug in tablets form with mean percentage recoveries of 100.1% with SWCAdSV and 99.99% with DPCAdSV. Precision and accuracy were also checked and were within the limits.

Original language	English
Pages (from-to)	37-51
Number of pages	15
Journal	International Journal of Electrochemical Science
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/s1452-3981(23)14973-x
State	Published - 2011

Keywords

Cathodic adsorptive striping voltammetry
Cyclic voltammetry
Nimodipine
Pharmaceutical formulations

ASJC Scopus subject areas

Electrochemistry

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10.1016/s1452-3981(23)14973-x

Cite this

@article{3587b2db02374cb4933538ab7d276c10,

title = "Assay of nimodipine - an anti hypertensive drug, in bulk form and pharmaceutical formulations by cathodic adsorptive stripping voltammetry",

abstract = "Adsorpitive Stripping square-wave voltammetry (SWV) and differential-pulse voltammetry (DPV) methods were developed, evaluated, and compared for the assay of nimodipine in pharmaceutical formulations. The proposed method allows determination of nimodipine in linear concentration range 2 × 10-5 to 2 × 10-6 mol L-1. The Limit of detection (LOD) and limit of quantification (LOQ) were noticed to be 7.11 ng/mL and 32.92 ng/mL respectively. The procedure was applied to the assay of the drug in tablets form with mean percentage recoveries of 100.1\% with SWCAdSV and 99.99\% with DPCAdSV. Precision and accuracy were also checked and were within the limits.",

keywords = "Cathodic adsorptive striping voltammetry, Cyclic voltammetry, Nimodipine, Pharmaceutical formulations",

author = "Gupta, \{Vinod K.\} and Rajeev Jain and Antonijevic, \{Milan M.\} and Hadi Khani and Siddiqui, \{M. N.\} and Ashish Dwivedi and Ritesh Mishra and Shilpi Agarwal",

year = "2011",

doi = "10.1016/s1452-3981(23)14973-x",

language = "English",

volume = "6",

pages = "37--51",

journal = "International Journal of Electrochemical Science",

issn = "1452-3981",

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TY - JOUR

T1 - Assay of nimodipine - an anti hypertensive drug, in bulk form and pharmaceutical formulations by cathodic adsorptive stripping voltammetry

AU - Gupta, Vinod K.

AU - Jain, Rajeev

AU - Antonijevic, Milan M.

AU - Khani, Hadi

AU - Siddiqui, M. N.

AU - Dwivedi, Ashish

AU - Mishra, Ritesh

AU - Agarwal, Shilpi

PY - 2011

Y1 - 2011

N2 - Adsorpitive Stripping square-wave voltammetry (SWV) and differential-pulse voltammetry (DPV) methods were developed, evaluated, and compared for the assay of nimodipine in pharmaceutical formulations. The proposed method allows determination of nimodipine in linear concentration range 2 × 10-5 to 2 × 10-6 mol L-1. The Limit of detection (LOD) and limit of quantification (LOQ) were noticed to be 7.11 ng/mL and 32.92 ng/mL respectively. The procedure was applied to the assay of the drug in tablets form with mean percentage recoveries of 100.1% with SWCAdSV and 99.99% with DPCAdSV. Precision and accuracy were also checked and were within the limits.

AB - Adsorpitive Stripping square-wave voltammetry (SWV) and differential-pulse voltammetry (DPV) methods were developed, evaluated, and compared for the assay of nimodipine in pharmaceutical formulations. The proposed method allows determination of nimodipine in linear concentration range 2 × 10-5 to 2 × 10-6 mol L-1. The Limit of detection (LOD) and limit of quantification (LOQ) were noticed to be 7.11 ng/mL and 32.92 ng/mL respectively. The procedure was applied to the assay of the drug in tablets form with mean percentage recoveries of 100.1% with SWCAdSV and 99.99% with DPCAdSV. Precision and accuracy were also checked and were within the limits.

KW - Cathodic adsorptive striping voltammetry

KW - Cyclic voltammetry

KW - Nimodipine

KW - Pharmaceutical formulations

UR - https://www.scopus.com/pages/publications/78650794353

U2 - 10.1016/s1452-3981(23)14973-x

DO - 10.1016/s1452-3981(23)14973-x

M3 - Article

AN - SCOPUS:78650794353

SN - 1452-3981

VL - 6

SP - 37

EP - 51

JO - International Journal of Electrochemical Science

JF - International Journal of Electrochemical Science

IS - 1

ER -

Assay of nimodipine - an anti hypertensive drug, in bulk form and pharmaceutical formulations by cathodic adsorptive stripping voltammetry

Abstract

Keywords

ASJC Scopus subject areas

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