TY - JOUR
T1 - Application of surfactant-templated ordered mesoporous material as sorbent in micro-solid phase extraction followed by liquid chromatography-triple quadrupole mass spectrometry for determination of perfluorinated carboxylic acids in aqueous media
AU - Lashgari, Maryam
AU - Basheer, Chanbasha
AU - Kee Lee, Hian
N1 - Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/8/15
Y1 - 2015/8/15
N2 - In the present study, micro-solid phase extraction (μ-SPE) followed by liquid chromatography-triple tandem mass spectrometery (LC-MS/MS) was developed for the determination of perfluorocarboxylic acids (PFCAs) at trace levels in water samples. The μ-SPE device comprised of a porous polypropylene membrane bag containing 5 mg sorbent. The membrane bag acted as a clean-up filter and prevented matrix compounds from interfering with the extraction process. Analysis was carried out by LC-MS/MS in negative electrospray ionization mode. MS/MS parameters were optimized for multiple reaction monitoring. Calcined and non-calcined MCM-41, as silica-ordered mesoporous materials, were used as sorbents in μ-SPE for the extraction of five PFCAs - perfluoropentanoic acid (PFPA), perfluoroheptanoic acid (PFHpA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) - from aqueous media. The performances of these two sorbents were compared with other sorbents such as octadecylsilane (C18) modified silica, HayeSep-A, HayeSep-B, and Porapak-R. It was found that non-calcined MCM-41 showed better extraction performance for the analytes considered. Parameters influencing extraction efficiency, such as desorption time, extraction time, desorption solvent, and salt concentration, were investigated. The effect of the matrix on MS signals (suppression or enhancement) was also evaluated. Only minor effects on ionization efficiencies were observed. The developed method proved to be convenient and offered good sensitivity and reproducibility. The limits of detection ranged from 0.02 to 0.08 ng L-1, with a relative standard deviations between 1.9 and 10.5. It was successfully applied to the extraction of PFCAs in river and rain water samples. As expected from the ubiquitous nature of PFCAs, contamination at low levels was detected for some analytes in the samples (with the highest concentration recorded for PFOA). Satisfactory relative recoveries ranging between 64% and 127% at spiking levels of 10 ng L-1 of each analyte were obtained.
AB - In the present study, micro-solid phase extraction (μ-SPE) followed by liquid chromatography-triple tandem mass spectrometery (LC-MS/MS) was developed for the determination of perfluorocarboxylic acids (PFCAs) at trace levels in water samples. The μ-SPE device comprised of a porous polypropylene membrane bag containing 5 mg sorbent. The membrane bag acted as a clean-up filter and prevented matrix compounds from interfering with the extraction process. Analysis was carried out by LC-MS/MS in negative electrospray ionization mode. MS/MS parameters were optimized for multiple reaction monitoring. Calcined and non-calcined MCM-41, as silica-ordered mesoporous materials, were used as sorbents in μ-SPE for the extraction of five PFCAs - perfluoropentanoic acid (PFPA), perfluoroheptanoic acid (PFHpA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) - from aqueous media. The performances of these two sorbents were compared with other sorbents such as octadecylsilane (C18) modified silica, HayeSep-A, HayeSep-B, and Porapak-R. It was found that non-calcined MCM-41 showed better extraction performance for the analytes considered. Parameters influencing extraction efficiency, such as desorption time, extraction time, desorption solvent, and salt concentration, were investigated. The effect of the matrix on MS signals (suppression or enhancement) was also evaluated. Only minor effects on ionization efficiencies were observed. The developed method proved to be convenient and offered good sensitivity and reproducibility. The limits of detection ranged from 0.02 to 0.08 ng L-1, with a relative standard deviations between 1.9 and 10.5. It was successfully applied to the extraction of PFCAs in river and rain water samples. As expected from the ubiquitous nature of PFCAs, contamination at low levels was detected for some analytes in the samples (with the highest concentration recorded for PFOA). Satisfactory relative recoveries ranging between 64% and 127% at spiking levels of 10 ng L-1 of each analyte were obtained.
KW - Micro-solid phase extraction
KW - Perfluorinated carboxylic acid
KW - Silica ordered mesoporous
UR - https://www.scopus.com/pages/publications/84928103418
U2 - 10.1016/j.talanta.2015.03.049
DO - 10.1016/j.talanta.2015.03.049
M3 - Article
AN - SCOPUS:84928103418
SN - 0039-9140
VL - 141
SP - 200
EP - 206
JO - Talanta
JF - Talanta
ER -