A versatile delivery platform comprising a novel composite of two biomaterials with proven namely carbonated apatite and poly(lactic-co-glycolic acid) (PLGA) was investigated. The controlled release strategy was based on the use of a polymer with acidic degradation products to control the dissolution of the basic apatitic component, resulting in protein release. The main objectives were to achieve sustained release to maintain the response and activity of bone forming cells. The scaffolds were found to support the attachment, differentiation and growth of pluripotent murine embryonic fibroblast cell line.