Antitumor potential of platinum(II) complexes of selenium donor ligands

Saeed Ahmad*, Anvarhusein A. Isab, Abdul Rahman Al-Arfaj

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Platinum(II) coordination compounds are widely applied in clinics as anticancer drugs. In this review, we provide a summary of the reports on cytotoxic properties of platinum(II) complexes of selenium donor ligands along with a brief description of their structural features. It has been observed that the platinum(II) complexes of selenones and selenoethers display reasonable antitumor properties and in some cases their cytotoxic activity is greater than cisplatin. The complexes containing NH3 ligands along with selenones were found to exhibit better cytotoxicity compared to the binary Pt-selenone complexes. The mechanistic insights showed that these complexes exert antitumor activity through reactive oxygen species (ROS) generation and induction of apoptosis. The platinum-selenoether coordination compounds can self-assemble into spherical aggregates capable of self-delivery. The self-assembled Pt-selenium aggregates induce cell apoptosis via ROS, which leads to high selectivity between cancer cells and normal cells in cytotoxicity assays.

Original languageEnglish
Article numbermfad020
JournalMetallomics
Volume15
Issue number4
DOIs
StatePublished - 2023

Bibliographical note

Publisher Copyright:
© 2023 Royal Society of Chemistry. All rights reserved.

Keywords

  • anticancer activity
  • apoptosis
  • platinum(II)
  • selenoethers
  • selenones
  • structure

ASJC Scopus subject areas

  • General Medicine

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