Antimicrobial Activities, Characterization and Synthesis of Organotin(IV) Complexes with Benzohydrazide Derivative

Aqeela Shaheen; Shahbaz Akhtar; Sajjad Ahmad; Aziz-Ur-Rehman; Abdul Saeed; Adnan Sharif; Mujahid Mustaqeem; Muhammad Nawaz; Syed Tahir Abbas Shah

doi:10.22207/JPAM.11.1.19

Antimicrobial Activities, Characterization and Synthesis of Organotin(IV) Complexes with Benzohydrazide Derivative

Aqeela Shaheen, Shahbaz Akhtar, Sajjad Ahmad, Aziz-Ur-Rehman^*, Abdul Saeed, Adnan Sharif, Mujahid Mustaqeem, Muhammad Nawaz, Syed Tahir Abbas Shah

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

An efficient and facile method for the synthesis of 2-hydroxy-N'-{(E)-[6′-(2H-1″2″,3″-Triazol-2″-yl)pyridin-3′-yl]methylidene}benzohydrazide via N-Arylation is described. The synthesized ligand was further coordinated with a variety of organotin(IV) salts. Structural elucidations of ligand and the complexes thus formed were made by CHN, IR, NMR and MS. The newly synthesized compounds were also screened for antifungal, antibacterial, cytotoxic and antiurease activities. The compounds 3,7,9 showed best antifungal activity against various strains while diorganotin(IV) moieties (7,8,10) showed excellent antibacterial activities. Compound 3 and 9 remained good antiurease and cytotoxic agents.

Original language	English
Pages (from-to)	141-150
Number of pages	10
Journal	Journal of Pure and Applied Microbiology
Volume	11
Issue number	1
DOIs	https://doi.org/10.22207/JPAM.11.1.19
State	Published - 1 Mar 2017
Externally published	Yes

Keywords

1,2,3-Triazol
2-hydroxybenzohydrazide
N-Arylation
Organotin(IV)

ASJC Scopus subject areas

Biotechnology
Microbiology
Applied Microbiology and Biotechnology

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10.22207/JPAM.11.1.19

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@article{dc34dd4d99564f37936182a55b5e3dbb,

title = "Antimicrobial Activities, Characterization and Synthesis of Organotin(IV) Complexes with Benzohydrazide Derivative",

abstract = "An efficient and facile method for the synthesis of 2-hydroxy-N'-\{(E)-[6′-(2H-1″2″,3″-Triazol-2″-yl)pyridin-3′-yl]methylidene\}benzohydrazide via N-Arylation is described. The synthesized ligand was further coordinated with a variety of organotin(IV) salts. Structural elucidations of ligand and the complexes thus formed were made by CHN, IR, NMR and MS. The newly synthesized compounds were also screened for antifungal, antibacterial, cytotoxic and antiurease activities. The compounds 3,7,9 showed best antifungal activity against various strains while diorganotin(IV) moieties (7,8,10) showed excellent antibacterial activities. Compound 3 and 9 remained good antiurease and cytotoxic agents.",

keywords = "1,2,3-Triazol, 2-hydroxybenzohydrazide, N-Arylation, Organotin(IV)",

author = "Aqeela Shaheen and Shahbaz Akhtar and Sajjad Ahmad and Aziz-Ur-Rehman and Abdul Saeed and Adnan Sharif and Mujahid Mustaqeem and Muhammad Nawaz and \{Abbas Shah\}, \{Syed Tahir\}",

year = "2017",

month = mar,

day = "1",

doi = "10.22207/JPAM.11.1.19",

language = "English",

volume = "11",

pages = "141--150",

journal = "Journal of Pure and Applied Microbiology",

issn = "0973-7510",

publisher = "Journal of Pure and Applied Microbiology",

number = "1",

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TY - JOUR

T1 - Antimicrobial Activities, Characterization and Synthesis of Organotin(IV) Complexes with Benzohydrazide Derivative

AU - Shaheen, Aqeela

AU - Akhtar, Shahbaz

AU - Ahmad, Sajjad

AU - Aziz-Ur-Rehman,

AU - Saeed, Abdul

AU - Sharif, Adnan

AU - Mustaqeem, Mujahid

AU - Nawaz, Muhammad

AU - Abbas Shah, Syed Tahir

PY - 2017/3/1

Y1 - 2017/3/1

N2 - An efficient and facile method for the synthesis of 2-hydroxy-N'-{(E)-[6′-(2H-1″2″,3″-Triazol-2″-yl)pyridin-3′-yl]methylidene}benzohydrazide via N-Arylation is described. The synthesized ligand was further coordinated with a variety of organotin(IV) salts. Structural elucidations of ligand and the complexes thus formed were made by CHN, IR, NMR and MS. The newly synthesized compounds were also screened for antifungal, antibacterial, cytotoxic and antiurease activities. The compounds 3,7,9 showed best antifungal activity against various strains while diorganotin(IV) moieties (7,8,10) showed excellent antibacterial activities. Compound 3 and 9 remained good antiurease and cytotoxic agents.

AB - An efficient and facile method for the synthesis of 2-hydroxy-N'-{(E)-[6′-(2H-1″2″,3″-Triazol-2″-yl)pyridin-3′-yl]methylidene}benzohydrazide via N-Arylation is described. The synthesized ligand was further coordinated with a variety of organotin(IV) salts. Structural elucidations of ligand and the complexes thus formed were made by CHN, IR, NMR and MS. The newly synthesized compounds were also screened for antifungal, antibacterial, cytotoxic and antiurease activities. The compounds 3,7,9 showed best antifungal activity against various strains while diorganotin(IV) moieties (7,8,10) showed excellent antibacterial activities. Compound 3 and 9 remained good antiurease and cytotoxic agents.

KW - 1,2,3-Triazol

KW - 2-hydroxybenzohydrazide

KW - N-Arylation

KW - Organotin(IV)

UR - https://www.scopus.com/pages/publications/85017601984

U2 - 10.22207/JPAM.11.1.19

DO - 10.22207/JPAM.11.1.19

M3 - Article

AN - SCOPUS:85017601984

SN - 0973-7510

VL - 11

SP - 141

EP - 150

JO - Journal of Pure and Applied Microbiology

JF - Journal of Pure and Applied Microbiology

IS - 1

ER -

Antimicrobial Activities, Characterization and Synthesis of Organotin(IV) Complexes with Benzohydrazide Derivative

Abstract

Keywords

ASJC Scopus subject areas

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