TY - JOUR
T1 - Anticancer activity and X-ray structure determination of gold(I) complexes of 2-(diphenylphosphanyl)-1-aminocyclohexane
AU - Sulaiman, Adam A.
AU - Alhoshani, Ali
AU - As Sobeai, Homood M.
AU - Alghanem, Meshal
AU - Abogosh, Ahmed K.
AU - Ahmad, Saeed
AU - Altaf, Muhammad
AU - Monim-ul-Mehboob, Muhammad
AU - Stoeckli-Evans, Helen
AU - Isab, Anvarhusein A.
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Phosphane gold(I) complexes, [Au(ACP)Cl] (1) and [Au(ACP)(S2CNR2)] (2–4) where ACP = 2-(diphenylphosphanyl)-1-aminocyclohexane or (2-aminocyclohexyl)diphenylphosphane, and R = methyl, ethyl, benzyl, were synthesized and characterized by elemental analysis, FTIR and multinuclear NMR spectroscopy. The molecular structure of one of the compounds, [Au(ACP)Cl] (1), was determined by single crystal X-ray diffraction analysis, which revealed a linear geometry around the Au(I) center. The crystal structure is stabilized by N–H⋯Cl hydrogen bonding interactions. The in vitro cytotoxicity of the complexes was evaluated against three cancer cells, A549 (human lung cancer), HeLa (human cervical cancer) and HepG2 (human liver cancer) cell lines. Three of the four complexes showed excellent in vitro cytotoxicity; their inhibition effect is much greater than that of cisplatin.
AB - Phosphane gold(I) complexes, [Au(ACP)Cl] (1) and [Au(ACP)(S2CNR2)] (2–4) where ACP = 2-(diphenylphosphanyl)-1-aminocyclohexane or (2-aminocyclohexyl)diphenylphosphane, and R = methyl, ethyl, benzyl, were synthesized and characterized by elemental analysis, FTIR and multinuclear NMR spectroscopy. The molecular structure of one of the compounds, [Au(ACP)Cl] (1), was determined by single crystal X-ray diffraction analysis, which revealed a linear geometry around the Au(I) center. The crystal structure is stabilized by N–H⋯Cl hydrogen bonding interactions. The in vitro cytotoxicity of the complexes was evaluated against three cancer cells, A549 (human lung cancer), HeLa (human cervical cancer) and HepG2 (human liver cancer) cell lines. Three of the four complexes showed excellent in vitro cytotoxicity; their inhibition effect is much greater than that of cisplatin.
KW - Anticancer activity
KW - Dithiocarbamates
KW - Gold(I)
KW - Phosphanes
KW - X-ray structure
UR - https://www.scopus.com/pages/publications/85082665120
U2 - 10.1016/j.poly.2020.114532
DO - 10.1016/j.poly.2020.114532
M3 - Article
AN - SCOPUS:85082665120
SN - 0277-5387
VL - 183
JO - Polyhedron
JF - Polyhedron
M1 - 114532
ER -
