Abstract
The chapter on antibody-based cancer therapies provides an overview of the use of monoclonal antibodies (mAbs) for the treatment of cancer. The chapter starts with an introduction to the basics of cancer immunotherapy and the different types of antibodies used in cancer treatment. The different types of mAbs are discussed, including naked mAbs, conjugated mAbs, and bispecific mAbs, and their mechanisms of action are explained. The chapter also covers the advantages and limitations of antibody-based therapies. The discussion then moves on to the different targets of mAbs in cancer treatment, including cancer-specific antigens, growth factor receptors, and immune checkpoints. The mechanisms of action and clinical applications of several FDA-approved antibody-based therapies, including trastuzumab, rituximab, and ipilimumab, are discussed in detail. The chapter also covers the emerging role of antibody-drug conjugates (ADCs) and immune checkpoint inhibitors (ICIs) in cancer therapy.
| Original language | English |
|---|---|
| Title of host publication | Cancer Targeting Therapies |
| Subtitle of host publication | Conventional and Advanced Perspectives |
| Publisher | CRC Press |
| Pages | 221-238 |
| Number of pages | 18 |
| ISBN (Electronic) | 9781000982930 |
| ISBN (Print) | 9781032426259 |
| DOIs | |
| State | Published - 1 Jan 2023 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2024 selection and editorial matter, Muhammad Yasir Ali, Shazia Anwer Bukhari; individual chapters, the contributors.
ASJC Scopus subject areas
- General Medicine
- General Pharmacology, Toxicology and Pharmaceutics
