Anti-HIV screening and molecular docking studies of benzothiazolyl thioureas

Hummera Rafique; Aamer Saeed; Fouzia Perveen; Muhammad N. Zafar; Muhammad Sharif; Najim Al Masoudi

Anti-HIV screening and molecular docking studies of benzothiazolyl thioureas

Hummera Rafique^*
, Aamer Saeed
, Fouzia Perveen
, Muhammad N. Zafar
, Muhammad Sharif
, Najim Al Masoudi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A new series of 1-(substituted benzothiazol-2-yl)-3-aroylthioureas (7a-k) were synthesized by treating variously substituted benzothiazolamines with in situ prepared isothiocyanates. The synthesized compounds were screened for their in vitro anti-HIV-1 and HIV-2 activity. The compounds 7e, 7f and 7i were found to exhibit potent anti-HIV-1 and HIV-2 activity.

Original language	English
Pages (from-to)	918-923
Number of pages	6
Journal	Latin American Journal of Pharmacy
Volume	36
Issue number	5
State	Published - 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.

Keywords

1-substituted (benzothiazol-2-yl)-3-aroylthioureas
2-aminobenzo-thiazoles
Anti-HIV activity

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{80cd4374fe19452fa74bfc880c3d8692,

title = "Anti-HIV screening and molecular docking studies of benzothiazolyl thioureas",

abstract = "A new series of 1-(substituted benzothiazol-2-yl)-3-aroylthioureas (7a-k) were synthesized by treating variously substituted benzothiazolamines with in situ prepared isothiocyanates. The synthesized compounds were screened for their in vitro anti-HIV-1 and HIV-2 activity. The compounds 7e, 7f and 7i were found to exhibit potent anti-HIV-1 and HIV-2 activity.",

keywords = "1-substituted (benzothiazol-2-yl)-3-aroylthioureas, 2-aminobenzo-thiazoles, Anti-HIV activity",

author = "Hummera Rafique and Aamer Saeed and Fouzia Perveen and Zafar, \{Muhammad N.\} and Muhammad Sharif and Masoudi, \{Najim Al\}",

year = "2017",

language = "English",

volume = "36",

pages = "918--923",

journal = "Latin American Journal of Pharmacy",

issn = "0326-2383",

publisher = "Colegio de Farmaceuticos de la Provincia de Buenos Aires",

number = "5",

}

TY - JOUR

T1 - Anti-HIV screening and molecular docking studies of benzothiazolyl thioureas

AU - Rafique, Hummera

AU - Saeed, Aamer

AU - Perveen, Fouzia

AU - Zafar, Muhammad N.

AU - Sharif, Muhammad

AU - Masoudi, Najim Al

PY - 2017

Y1 - 2017

N2 - A new series of 1-(substituted benzothiazol-2-yl)-3-aroylthioureas (7a-k) were synthesized by treating variously substituted benzothiazolamines with in situ prepared isothiocyanates. The synthesized compounds were screened for their in vitro anti-HIV-1 and HIV-2 activity. The compounds 7e, 7f and 7i were found to exhibit potent anti-HIV-1 and HIV-2 activity.

AB - A new series of 1-(substituted benzothiazol-2-yl)-3-aroylthioureas (7a-k) were synthesized by treating variously substituted benzothiazolamines with in situ prepared isothiocyanates. The synthesized compounds were screened for their in vitro anti-HIV-1 and HIV-2 activity. The compounds 7e, 7f and 7i were found to exhibit potent anti-HIV-1 and HIV-2 activity.

KW - 1-substituted (benzothiazol-2-yl)-3-aroylthioureas

KW - 2-aminobenzo-thiazoles

KW - Anti-HIV activity

UR - https://www.scopus.com/pages/publications/85018285166

M3 - Article

AN - SCOPUS:85018285166

SN - 0326-2383

VL - 36

SP - 918

EP - 923

JO - Latin American Journal of Pharmacy

JF - Latin American Journal of Pharmacy

IS - 5

ER -

Anti-HIV screening and molecular docking studies of benzothiazolyl thioureas

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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Cite this