Abstract
Aim: Biliary tract carcinoma (BTC), including gall bladder carcinoma (GBC) and biliary duct carcinoma (BDC), has a poor prognosis. Comprehensive genomic profiling has important roles in evaluation of the carcinogenesis of BTC. Materials & methods: We examined somatic copy number alterations (SCNAs) using a single nucleotide polymorphism array system to analyze 36 BTC samples (11 GBCs and 25 BDCs). Results: In hierarchical cluster analysis, two clusters were identified (subgroup 1 with low SCNAs and subgroup 2 with high SCNAs). GBC was predominant in subgroup 1, whereas BDC was predominant in subgroup 2, suggesting that GBC and BDC had different genetic backgrounds in terms of SCNAs. Conclusion: These findings could be helpful for establishing the molecular carcinogenesis of BTCs.
| Original language | English |
|---|---|
| Article number | FSO766 |
| Journal | Future Science OA |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2022 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2021 Tamotsu Sugai.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- bile duct cancer
- biliary tract carcinoma
- carcinogenesis
- cluster analysis
- crypt isolation method
- gall bladder cancer
- molecular alteration
- prognosis
- single nucleotide polymorphism array
- somatic copy number alteration
ASJC Scopus subject areas
- Biotechnology
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