An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase

Nisar Ullah; Shamsuddeen A. Haladu; Basem A. Mosa

doi:10.1016/j.tetlet.2010.10.164

An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase

Nisar Ullah^*
, Shamsuddeen A. Haladu
, Basem A. Mosa

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

An improved total synthesis of spermatinamine, an inhibitor of the anticancer target, isoprenylcysteine carboxy methyltransferase (Icmt) was accomplished from the commercially available 3,4-dibromo-4-hydroxybenzaldehyde via a high yielding reaction sequence in an overall yield of 31%.

Original language	English
Pages (from-to)	212-214
Number of pages	3
Journal	Tetrahedron Letters
Volume	52
Issue number	2
DOIs	https://doi.org/10.1016/j.tetlet.2010.10.164
State	Published - 12 Jan 2011

Bibliographical note

Funding Information:
The research facilities and financial support by KFUPM Grant No: FT090014 are gratefully acknowledged.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer drug
Azlactone formation
Icmt inhibitor
Spermatinamine

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2010.10.164

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title = "An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase",

abstract = "An improved total synthesis of spermatinamine, an inhibitor of the anticancer target, isoprenylcysteine carboxy methyltransferase (Icmt) was accomplished from the commercially available 3,4-dibromo-4-hydroxybenzaldehyde via a high yielding reaction sequence in an overall yield of 31\%.",

keywords = "Anticancer drug, Azlactone formation, Icmt inhibitor, Spermatinamine",

author = "Nisar Ullah and Haladu, \{Shamsuddeen A.\} and Mosa, \{Basem A.\}",

note = "Funding Information: The research facilities and financial support by KFUPM Grant No: FT090014 are gratefully acknowledged. ",

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doi = "10.1016/j.tetlet.2010.10.164",

language = "English",

volume = "52",

pages = "212--214",

journal = "Tetrahedron Letters",

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T1 - An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase

AU - Ullah, Nisar

AU - Haladu, Shamsuddeen A.

AU - Mosa, Basem A.

N1 - Funding Information: The research facilities and financial support by KFUPM Grant No: FT090014 are gratefully acknowledged.

PY - 2011/1/12

Y1 - 2011/1/12

N2 - An improved total synthesis of spermatinamine, an inhibitor of the anticancer target, isoprenylcysteine carboxy methyltransferase (Icmt) was accomplished from the commercially available 3,4-dibromo-4-hydroxybenzaldehyde via a high yielding reaction sequence in an overall yield of 31%.

AB - An improved total synthesis of spermatinamine, an inhibitor of the anticancer target, isoprenylcysteine carboxy methyltransferase (Icmt) was accomplished from the commercially available 3,4-dibromo-4-hydroxybenzaldehyde via a high yielding reaction sequence in an overall yield of 31%.

KW - Anticancer drug

KW - Azlactone formation

KW - Icmt inhibitor

KW - Spermatinamine

UR - https://www.scopus.com/pages/publications/78650019754

U2 - 10.1016/j.tetlet.2010.10.164

DO - 10.1016/j.tetlet.2010.10.164

M3 - Article

AN - SCOPUS:78650019754

SN - 0040-4039

VL - 52

SP - 212

EP - 214

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 2

ER -

An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

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