An efficient copper(I) complex catalyzed Sonogashira type cross-coupling of aryl halides with terminal alkynes

K. G. Thakur; E. A. Jaseer; Ajay B. Naidu; Govindasamy Sekar

doi:10.1016/j.tetlet.2009.03.146

An efficient copper(I) complex catalyzed Sonogashira type cross-coupling of aryl halides with terminal alkynes

K. G. Thakur
, E. A. Jaseer
, Ajay B. Naidu
, Govindasamy Sekar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

A wide range of arylated alkynes are synthesized from the corresponding aryl halides and terminal alkynes through Sonogashira type cross-coupling reactions through C(aryl)-C bond formation in the presence of a catalytic amount of N,N′-dibenzyl BINAM-CuI complex under mild reaction conditions.

Original language	English
Pages (from-to)	2865-2869
Number of pages	5
Journal	Tetrahedron Letters
Volume	50
Issue number	24
DOIs	https://doi.org/10.1016/j.tetlet.2009.03.146
State	Published - 17 Jun 2009
Externally published	Yes

Bibliographical note

Funding Information:
We thank DST (Project No. SR/S1/OC-06/2008), New Delhi for the financial support. K.G.T. and E.A.J. thank CSIR and ABN thanks UGC for senior research fellowship. We thank DST, New Delhi, for the funding towards the 400 MHz NMR machine to the Department of Chemistry, IIT-Madras under the IRPHA scheme and ESI-MS facility under the FIST programme.

Keywords

Arylated alkynes
C-C bond formation
Copper catalyst
Coupling reaction
Sonogashira coupling

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2009.03.146

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title = "An efficient copper(I) complex catalyzed Sonogashira type cross-coupling of aryl halides with terminal alkynes",

abstract = "A wide range of arylated alkynes are synthesized from the corresponding aryl halides and terminal alkynes through Sonogashira type cross-coupling reactions through C(aryl)-C bond formation in the presence of a catalytic amount of N,N′-dibenzyl BINAM-CuI complex under mild reaction conditions.",

keywords = "Arylated alkynes, C-C bond formation, Copper catalyst, Coupling reaction, Sonogashira coupling",

author = "Thakur, \{K. G.\} and Jaseer, \{E. A.\} and Naidu, \{Ajay B.\} and Govindasamy Sekar",

note = "Funding Information: We thank DST (Project No. SR/S1/OC-06/2008), New Delhi for the financial support. K.G.T. and E.A.J. thank CSIR and ABN thanks UGC for senior research fellowship. We thank DST, New Delhi, for the funding towards the 400 MHz NMR machine to the Department of Chemistry, IIT-Madras under the IRPHA scheme and ESI-MS facility under the FIST programme.",

year = "2009",

month = jun,

day = "17",

doi = "10.1016/j.tetlet.2009.03.146",

language = "English",

volume = "50",

pages = "2865--2869",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - An efficient copper(I) complex catalyzed Sonogashira type cross-coupling of aryl halides with terminal alkynes

AU - Thakur, K. G.

AU - Jaseer, E. A.

AU - Naidu, Ajay B.

AU - Sekar, Govindasamy

N1 - Funding Information: We thank DST (Project No. SR/S1/OC-06/2008), New Delhi for the financial support. K.G.T. and E.A.J. thank CSIR and ABN thanks UGC for senior research fellowship. We thank DST, New Delhi, for the funding towards the 400 MHz NMR machine to the Department of Chemistry, IIT-Madras under the IRPHA scheme and ESI-MS facility under the FIST programme.

PY - 2009/6/17

Y1 - 2009/6/17

N2 - A wide range of arylated alkynes are synthesized from the corresponding aryl halides and terminal alkynes through Sonogashira type cross-coupling reactions through C(aryl)-C bond formation in the presence of a catalytic amount of N,N′-dibenzyl BINAM-CuI complex under mild reaction conditions.

AB - A wide range of arylated alkynes are synthesized from the corresponding aryl halides and terminal alkynes through Sonogashira type cross-coupling reactions through C(aryl)-C bond formation in the presence of a catalytic amount of N,N′-dibenzyl BINAM-CuI complex under mild reaction conditions.

KW - Arylated alkynes

KW - C-C bond formation

KW - Copper catalyst

KW - Coupling reaction

KW - Sonogashira coupling

UR - https://www.scopus.com/pages/publications/65249154884

U2 - 10.1016/j.tetlet.2009.03.146

DO - 10.1016/j.tetlet.2009.03.146

M3 - Article

AN - SCOPUS:65249154884

SN - 0040-4039

VL - 50

SP - 2865

EP - 2869

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 24

ER -

An efficient copper(I) complex catalyzed Sonogashira type cross-coupling of aryl halides with terminal alkynes

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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