Amine functionalized ZrO2 nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging

Muhammad Nawaz Tahir; Ruben Ragg; Filipe Natalio; Jugal Kishore Sahoo; Phillip Daniel; Kaloian Koynov; Dennis Strand; Susanne Strand; Wolfgang Tremel

doi:10.1039/c4tb01959h

Amine functionalized ZrO₂ nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging

Muhammad Nawaz Tahir^*, Ruben Ragg, Filipe Natalio, Jugal Kishore Sahoo, Phillip Daniel, Kaloian Koynov, Dennis Strand, Susanne Strand, Wolfgang Tremel

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Surface functionalized ZrO₂ nanoparticles show strong photoluminescence and are a versatile tool for cellular targeting due to their chemical functionality. They are highly photostable, biocompatible and amenable to coupling with bioligands (e.g. secondary goat anti-rabbit antibody (GAR) and tri-phenyl phosphine (TPP)) via carbodiimide chemistry. Antibody (GAR) functionalized ZrO₂ nanoparticles were used to image the nuclear protein Sirt6, whereas triphenyl phosphonium ion (TPP) functionalized ZrO₂ nanoparticles specifically targeted the mitochondria. The versatility and easiness of the ZrO₂ surface modification opens up new possibilities for designing non-toxic water dispersible and photostable photoluminescent NPs.

Original language	English
Pages (from-to)	2371-2377
Number of pages	7
Journal	Journal of Materials Chemistry B
Volume	3
Issue number	11
DOIs	https://doi.org/10.1039/c4tb01959h
State	Published - 21 Mar 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2015.

ASJC Scopus subject areas

General Chemistry
Biomedical Engineering
General Materials Science

Access to Document

10.1039/c4tb01959h

Cite this

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title = "Amine functionalized ZrO2 nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging",

abstract = "Surface functionalized ZrO2 nanoparticles show strong photoluminescence and are a versatile tool for cellular targeting due to their chemical functionality. They are highly photostable, biocompatible and amenable to coupling with bioligands (e.g. secondary goat anti-rabbit antibody (GAR) and tri-phenyl phosphine (TPP)) via carbodiimide chemistry. Antibody (GAR) functionalized ZrO2 nanoparticles were used to image the nuclear protein Sirt6, whereas triphenyl phosphonium ion (TPP) functionalized ZrO2 nanoparticles specifically targeted the mitochondria. The versatility and easiness of the ZrO2 surface modification opens up new possibilities for designing non-toxic water dispersible and photostable photoluminescent NPs.",

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AU - Tahir, Muhammad Nawaz

AU - Ragg, Ruben

AU - Natalio, Filipe

AU - Sahoo, Jugal Kishore

AU - Daniel, Phillip

AU - Koynov, Kaloian

AU - Strand, Dennis

AU - Strand, Susanne

AU - Tremel, Wolfgang

PY - 2015/3/21

Y1 - 2015/3/21

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AB - Surface functionalized ZrO2 nanoparticles show strong photoluminescence and are a versatile tool for cellular targeting due to their chemical functionality. They are highly photostable, biocompatible and amenable to coupling with bioligands (e.g. secondary goat anti-rabbit antibody (GAR) and tri-phenyl phosphine (TPP)) via carbodiimide chemistry. Antibody (GAR) functionalized ZrO2 nanoparticles were used to image the nuclear protein Sirt6, whereas triphenyl phosphonium ion (TPP) functionalized ZrO2 nanoparticles specifically targeted the mitochondria. The versatility and easiness of the ZrO2 surface modification opens up new possibilities for designing non-toxic water dispersible and photostable photoluminescent NPs.

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