Amberlyst-15® in ionic liquid: an efficient and recyclable reagent for the benzylation and hydroalkylation of β-dicarbonyl compounds

Ziyauddin S. Qureshi; Krishna M. Deshmukh; Pawan J. Tambade; Bhalchandra M. Bhanage

doi:10.1016/j.tetlet.2009.11.122

Amberlyst-15® in ionic liquid: an efficient and recyclable reagent for the benzylation and hydroalkylation of β-dicarbonyl compounds

Ziyauddin S. Qureshi
, Krishna M. Deshmukh
, Pawan J. Tambade
, Bhalchandra M. Bhanage^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Benzylation and hydroalkylation of 1,3-dicarbonyl compounds using Amberlyst-15 immobilized in ionic liquid [Bmim][PF₆] as an efficient reusable reagent was studied. The reagent was compared with other solid acid reagents along with role of the ionic liquid. The effect of various reaction parameters like type of reagent, solvent, substrate molar ratio, reaction time, and temperature were studied. Present protocol is advantageous due to the ease in handling of reagent, simple work-up procedure, economical and environmentally benign process. The products were obtained in good to excellent yield and applicable to wide variety of substrates.

Original language	English
Pages (from-to)	724-729
Number of pages	6
Journal	Tetrahedron Letters
Volume	51
Issue number	4
DOIs	https://doi.org/10.1016/j.tetlet.2009.11.122
State	Published - 27 Jan 2010
Externally published	Yes

Bibliographical note

Funding Information:
The financial assistance from Indira Gandhi Centre for Atomic Research (IGCAR) Kalpakkam, India is kindly acknowledged.

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Amberlyst-15{\textregistered} in ionic liquid: an efficient and recyclable reagent for the benzylation and hydroalkylation of β-dicarbonyl compounds",

abstract = "Benzylation and hydroalkylation of 1,3-dicarbonyl compounds using Amberlyst-15 immobilized in ionic liquid [Bmim][PF6] as an efficient reusable reagent was studied. The reagent was compared with other solid acid reagents along with role of the ionic liquid. The effect of various reaction parameters like type of reagent, solvent, substrate molar ratio, reaction time, and temperature were studied. Present protocol is advantageous due to the ease in handling of reagent, simple work-up procedure, economical and environmentally benign process. The products were obtained in good to excellent yield and applicable to wide variety of substrates.",

author = "Qureshi, \{Ziyauddin S.\} and Deshmukh, \{Krishna M.\} and Tambade, \{Pawan J.\} and Bhanage, \{Bhalchandra M.\}",

note = "Funding Information: The financial assistance from Indira Gandhi Centre for Atomic Research (IGCAR) Kalpakkam, India is kindly acknowledged.",

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doi = "10.1016/j.tetlet.2009.11.122",

language = "English",

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pages = "724--729",

journal = "Tetrahedron Letters",

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T1 - Amberlyst-15® in ionic liquid

T2 - an efficient and recyclable reagent for the benzylation and hydroalkylation of β-dicarbonyl compounds

AU - Qureshi, Ziyauddin S.

AU - Deshmukh, Krishna M.

AU - Tambade, Pawan J.

AU - Bhanage, Bhalchandra M.

N1 - Funding Information: The financial assistance from Indira Gandhi Centre for Atomic Research (IGCAR) Kalpakkam, India is kindly acknowledged.

PY - 2010/1/27

Y1 - 2010/1/27

N2 - Benzylation and hydroalkylation of 1,3-dicarbonyl compounds using Amberlyst-15 immobilized in ionic liquid [Bmim][PF6] as an efficient reusable reagent was studied. The reagent was compared with other solid acid reagents along with role of the ionic liquid. The effect of various reaction parameters like type of reagent, solvent, substrate molar ratio, reaction time, and temperature were studied. Present protocol is advantageous due to the ease in handling of reagent, simple work-up procedure, economical and environmentally benign process. The products were obtained in good to excellent yield and applicable to wide variety of substrates.

AB - Benzylation and hydroalkylation of 1,3-dicarbonyl compounds using Amberlyst-15 immobilized in ionic liquid [Bmim][PF6] as an efficient reusable reagent was studied. The reagent was compared with other solid acid reagents along with role of the ionic liquid. The effect of various reaction parameters like type of reagent, solvent, substrate molar ratio, reaction time, and temperature were studied. Present protocol is advantageous due to the ease in handling of reagent, simple work-up procedure, economical and environmentally benign process. The products were obtained in good to excellent yield and applicable to wide variety of substrates.

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DO - 10.1016/j.tetlet.2009.11.122

M3 - Article

AN - SCOPUS:72449207687

SN - 0040-4039

VL - 51

SP - 724

EP - 729

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 4

ER -

Amberlyst-15® in ionic liquid: an efficient and recyclable reagent for the benzylation and hydroalkylation of β-dicarbonyl compounds

Abstract

Bibliographical note

ASJC Scopus subject areas

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