Alcohol Dehydrogenases with anti-Prelog Stereopreference in Synthesis of Enantiopure Alcohols

Musa M. Musa

doi:10.1002/open.202100251

Alcohol Dehydrogenases with anti-Prelog Stereopreference in Synthesis of Enantiopure Alcohols

Musa M. Musa^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Biocatalytic production of both enantiomers of optically active alcohols with high enantiopurities is of great interest in industry. Alcohol dehydrogenases (ADHs) represent an important class of enzymes that could be used as catalysts to produce optically active alcohols from their corresponding prochiral ketones. This review covers examples of the synthesis of optically active alcohols using ADHs that exhibit anti-Prelog stereopreference. Both wild-type and engineered ADHs that exhibit anti-Prelog stereopreference are highlighted.

Original language	English
Article number	e202100251
Journal	ChemistryOpen
Volume	11
Issue number	4
DOIs	https://doi.org/10.1002/open.202100251
State	Published - Apr 2022

Bibliographical note

Publisher Copyright:
© 2022 The Authors. Published by Wiley-VCH GmbH.

Keywords

alcohol dehydrogenases
anti-Prelog
asymmetric reduction
biocatalysis
enantiopure alcohols

ASJC Scopus subject areas

General Chemistry

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10.1002/open.202100251

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title = "Alcohol Dehydrogenases with anti-Prelog Stereopreference in Synthesis of Enantiopure Alcohols",

abstract = "Biocatalytic production of both enantiomers of optically active alcohols with high enantiopurities is of great interest in industry. Alcohol dehydrogenases (ADHs) represent an important class of enzymes that could be used as catalysts to produce optically active alcohols from their corresponding prochiral ketones. This review covers examples of the synthesis of optically active alcohols using ADHs that exhibit anti-Prelog stereopreference. Both wild-type and engineered ADHs that exhibit anti-Prelog stereopreference are highlighted.",

keywords = "alcohol dehydrogenases, anti-Prelog, asymmetric reduction, biocatalysis, enantiopure alcohols",

author = "Musa, {Musa M.}",

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N2 - Biocatalytic production of both enantiomers of optically active alcohols with high enantiopurities is of great interest in industry. Alcohol dehydrogenases (ADHs) represent an important class of enzymes that could be used as catalysts to produce optically active alcohols from their corresponding prochiral ketones. This review covers examples of the synthesis of optically active alcohols using ADHs that exhibit anti-Prelog stereopreference. Both wild-type and engineered ADHs that exhibit anti-Prelog stereopreference are highlighted.

AB - Biocatalytic production of both enantiomers of optically active alcohols with high enantiopurities is of great interest in industry. Alcohol dehydrogenases (ADHs) represent an important class of enzymes that could be used as catalysts to produce optically active alcohols from their corresponding prochiral ketones. This review covers examples of the synthesis of optically active alcohols using ADHs that exhibit anti-Prelog stereopreference. Both wild-type and engineered ADHs that exhibit anti-Prelog stereopreference are highlighted.

KW - alcohol dehydrogenases

KW - anti-Prelog

KW - asymmetric reduction

KW - biocatalysis

KW - enantiopure alcohols

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JF - ChemistryOpen

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ER -

Alcohol Dehydrogenases with anti-Prelog Stereopreference in Synthesis of Enantiopure Alcohols

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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