A splice-switch oligonucleotide loaded self-cleavable DNA nanogel

Yuwei Hu; Feng Chen; Hongfang Lu; Susi Tan; Yujie Ke; Wei Wei Loh; Eugene Jia Hao Soh; Agarwal Taniya; Tommaso Tabaglio; Dave Keng Boon Wee; Jackie Y. Ying

doi:10.1039/d4cc01942c

A splice-switch oligonucleotide loaded self-cleavable DNA nanogel

Yuwei Hu^*
, Feng Chen
, Hongfang Lu
, Susi Tan
, Yujie Ke
, Wei Wei Loh
, Eugene Jia Hao Soh
, Agarwal Taniya
, Tommaso Tabaglio
, Dave Keng Boon Wee
, Jackie Y. Ying^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.

Original language	English
Pages (from-to)	11516-11519
Number of pages	4
Journal	Chemical Communications
Volume	60
Issue number	81
DOIs	https://doi.org/10.1039/d4cc01942c
State	Published - 12 Sep 2024
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2024 The Royal Society of Chemistry.

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/d4cc01942c

Cite this

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abstract = "A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.",

author = "Yuwei Hu and Feng Chen and Hongfang Lu and Susi Tan and Yujie Ke and Loh, \{Wei Wei\} and Soh, \{Eugene Jia Hao\} and Agarwal Taniya and Tommaso Tabaglio and Wee, \{Dave Keng Boon\} and Ying, \{Jackie Y.\}",

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T1 - A splice-switch oligonucleotide loaded self-cleavable DNA nanogel

AU - Hu, Yuwei

AU - Chen, Feng

AU - Lu, Hongfang

AU - Tan, Susi

AU - Ke, Yujie

AU - Loh, Wei Wei

AU - Soh, Eugene Jia Hao

AU - Taniya, Agarwal

AU - Tabaglio, Tommaso

AU - Wee, Dave Keng Boon

AU - Ying, Jackie Y.

PY - 2024/9/12

Y1 - 2024/9/12

N2 - A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.

AB - A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.

UR - https://www.scopus.com/pages/publications/85205772680

U2 - 10.1039/d4cc01942c

DO - 10.1039/d4cc01942c

M3 - Article

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AN - SCOPUS:85205772680

SN - 1359-7345

VL - 60

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JO - Chemical Communications

JF - Chemical Communications

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