A perylenemonoimide-based fluorescent probe: ultrasensitive and selective tracing of endogenous peroxynitrite in living cells

Aasif Khan; Vinod Kumar Meena; Akshay Silswal; Apurba Lal Koner

doi:10.1039/d3an01469j

A perylenemonoimide-based fluorescent probe: ultrasensitive and selective tracing of endogenous peroxynitrite in living cells

Aasif Khan
, Vinod Kumar Meena
, Akshay Silswal
, Apurba Lal Koner^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Peroxynitrite (ONOO⁻), a highly reactive species, plays a key role in various physiological and pathological processes. Herein, a red-emitting fluorescent reporter perylenemonoimide-boronate ester (PMI-BE) was synthesized and utilized for ultrasensitive detection of ONOO⁻. The unique feature of PMI-BE is its nanomolar sensitivity with high selectivity towards ONOO⁻. Moreover, PMI-BE also detects endogenously generated ONOO⁻ in live cells.

Original language	English
Pages (from-to)	5851-5855
Number of pages	5
Journal	The Analyst
Volume	148
Issue number	23
DOIs	https://doi.org/10.1039/d3an01469j
State	Published - 18 Oct 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023 The Royal Society of Chemistry.

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Environmental Chemistry
Spectroscopy
Electrochemistry

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title = "A perylenemonoimide-based fluorescent probe: ultrasensitive and selective tracing of endogenous peroxynitrite in living cells",

abstract = "Peroxynitrite (ONOO−), a highly reactive species, plays a key role in various physiological and pathological processes. Herein, a red-emitting fluorescent reporter perylenemonoimide-boronate ester (PMI-BE) was synthesized and utilized for ultrasensitive detection of ONOO−. The unique feature of PMI-BE is its nanomolar sensitivity with high selectivity towards ONOO−. Moreover, PMI-BE also detects endogenously generated ONOO− in live cells.",

author = "Aasif Khan and Meena, \{Vinod Kumar\} and Akshay Silswal and Koner, \{Apurba Lal\}",

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AU - Khan, Aasif

AU - Meena, Vinod Kumar

AU - Silswal, Akshay

AU - Koner, Apurba Lal

PY - 2023/10/18

Y1 - 2023/10/18

N2 - Peroxynitrite (ONOO−), a highly reactive species, plays a key role in various physiological and pathological processes. Herein, a red-emitting fluorescent reporter perylenemonoimide-boronate ester (PMI-BE) was synthesized and utilized for ultrasensitive detection of ONOO−. The unique feature of PMI-BE is its nanomolar sensitivity with high selectivity towards ONOO−. Moreover, PMI-BE also detects endogenously generated ONOO− in live cells.

AB - Peroxynitrite (ONOO−), a highly reactive species, plays a key role in various physiological and pathological processes. Herein, a red-emitting fluorescent reporter perylenemonoimide-boronate ester (PMI-BE) was synthesized and utilized for ultrasensitive detection of ONOO−. The unique feature of PMI-BE is its nanomolar sensitivity with high selectivity towards ONOO−. Moreover, PMI-BE also detects endogenously generated ONOO− in live cells.

UR - https://www.scopus.com/pages/publications/85175537800

U2 - 10.1039/d3an01469j

DO - 10.1039/d3an01469j

M3 - Article

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ER -

A perylenemonoimide-based fluorescent probe: ultrasensitive and selective tracing of endogenous peroxynitrite in living cells

Abstract

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ASJC Scopus subject areas

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