A novel cyclic dinuclear gold(i) complex induces anticancer activity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells

Ahmed K. Abogosh; Meshal K. Alghanem; Saeed Ahmad; Abdullah Al-Asmari; Homood M. As Sobeai; Adam A.A. Sulaiman; Mohammed Fettouhi; Saheed A. Popoola; Ali Alhoshani; Anvarhusein A. Isab

doi:10.1039/d1dt03546k

A novel cyclic dinuclear gold(i) complex induces anticancer activity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells

Ahmed K. Abogosh
, Meshal K. Alghanem
, Saeed Ahmad
, Abdullah Al-Asmari
, Homood M. As Sobeai
, Adam A.A. Sulaiman
, Mohammed Fettouhi
, Saheed A. Popoola
, Ali Alhoshani
, Anvarhusein A. Isab^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A new dinuclear cyclic gold(i) complex [Au₂(DCyPA)₂](PF₆)₂, 1, based on bis[2-(dicyclohexylphosphano)ethyl]amine (DCyPA) has been synthesized and characterized by elemental analysis, IR and NMR spectroscopy, and X-ray crystallography. In the dinuclear complex cation [Au₂(DCyPA)₂]²⁺, the two gold(i) ions are bridged by the ligand bis[2-(dicyclohexylphosphano)ethyl]amine (DCyPA) giving rise to a 16-membered ring centrosymmetric metallacycle. The cytotoxicity of the complex was evaluated against the triple-negative human breast cancer cells MDA-MB-231. In order to understand the mechanism of the cytotoxic behavior, a variety of assays, including Annexin V-FITC/Propidium iodide double staining, ROS production, and mitochondrial membrane potential and migration assays were carried out. The results indicated that complex 1 induced cytotoxicity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells.

Original language	English
Pages (from-to)	2760-2769
Number of pages	10
Journal	Dalton Transactions
Volume	51
Issue number	7
DOIs	https://doi.org/10.1039/d1dt03546k
State	Published - 21 Feb 2022

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Inorganic Chemistry

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10.1039/d1dt03546k

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Abogosh, A. K., Alghanem, M. K., Ahmad, S., Al-Asmari, A., As Sobeai, H. M., Sulaiman, A. A. A., Fettouhi, M., Popoola, S. A., Alhoshani, A., & Isab, A. A. (2022). A novel cyclic dinuclear gold(i) complex induces anticancer activity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells. Dalton Transactions, 51(7), 2760-2769. https://doi.org/10.1039/d1dt03546k

@article{3558e6e7a22e45d08ac8aee5e1e8a43c,

title = "A novel cyclic dinuclear gold(i) complex induces anticancer activity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells",

abstract = "A new dinuclear cyclic gold(i) complex [Au2(DCyPA)2](PF6)2, 1, based on bis[2-(dicyclohexylphosphano)ethyl]amine (DCyPA) has been synthesized and characterized by elemental analysis, IR and NMR spectroscopy, and X-ray crystallography. In the dinuclear complex cation [Au2(DCyPA)2]2+, the two gold(i) ions are bridged by the ligand bis[2-(dicyclohexylphosphano)ethyl]amine (DCyPA) giving rise to a 16-membered ring centrosymmetric metallacycle. The cytotoxicity of the complex was evaluated against the triple-negative human breast cancer cells MDA-MB-231. In order to understand the mechanism of the cytotoxic behavior, a variety of assays, including Annexin V-FITC/Propidium iodide double staining, ROS production, and mitochondrial membrane potential and migration assays were carried out. The results indicated that complex 1 induced cytotoxicity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells.",

author = "Abogosh, \{Ahmed K.\} and Alghanem, \{Meshal K.\} and Saeed Ahmad and Abdullah Al-Asmari and \{As Sobeai\}, \{Homood M.\} and Sulaiman, \{Adam A.A.\} and Mohammed Fettouhi and Popoola, \{Saheed A.\} and Ali Alhoshani and Isab, \{Anvarhusein A.\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry",

year = "2022",

month = feb,

day = "21",

doi = "10.1039/d1dt03546k",

language = "English",

volume = "51",

pages = "2760--2769",

journal = "Dalton Transactions",

issn = "1477-9226",

publisher = "Royal Society of Chemistry",

number = "7",

}

Abogosh, AK, Alghanem, MK, Ahmad, S, Al-Asmari, A, As Sobeai, HM, Sulaiman, AAA, Fettouhi, M, Popoola, SA, Alhoshani, A & Isab, AA 2022, 'A novel cyclic dinuclear gold(i) complex induces anticancer activity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells', Dalton Transactions, vol. 51, no. 7, pp. 2760-2769. https://doi.org/10.1039/d1dt03546k

TY - JOUR

T1 - A novel cyclic dinuclear gold(i) complex induces anticancer activity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells

AU - Abogosh, Ahmed K.

AU - Alghanem, Meshal K.

AU - Ahmad, Saeed

AU - Al-Asmari, Abdullah

AU - As Sobeai, Homood M.

AU - Sulaiman, Adam A.A.

AU - Fettouhi, Mohammed

AU - Popoola, Saheed A.

AU - Alhoshani, Ali

AU - Isab, Anvarhusein A.

PY - 2022/2/21

Y1 - 2022/2/21

N2 - A new dinuclear cyclic gold(i) complex [Au2(DCyPA)2](PF6)2, 1, based on bis[2-(dicyclohexylphosphano)ethyl]amine (DCyPA) has been synthesized and characterized by elemental analysis, IR and NMR spectroscopy, and X-ray crystallography. In the dinuclear complex cation [Au2(DCyPA)2]2+, the two gold(i) ions are bridged by the ligand bis[2-(dicyclohexylphosphano)ethyl]amine (DCyPA) giving rise to a 16-membered ring centrosymmetric metallacycle. The cytotoxicity of the complex was evaluated against the triple-negative human breast cancer cells MDA-MB-231. In order to understand the mechanism of the cytotoxic behavior, a variety of assays, including Annexin V-FITC/Propidium iodide double staining, ROS production, and mitochondrial membrane potential and migration assays were carried out. The results indicated that complex 1 induced cytotoxicity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells.

AB - A new dinuclear cyclic gold(i) complex [Au2(DCyPA)2](PF6)2, 1, based on bis[2-(dicyclohexylphosphano)ethyl]amine (DCyPA) has been synthesized and characterized by elemental analysis, IR and NMR spectroscopy, and X-ray crystallography. In the dinuclear complex cation [Au2(DCyPA)2]2+, the two gold(i) ions are bridged by the ligand bis[2-(dicyclohexylphosphano)ethyl]amine (DCyPA) giving rise to a 16-membered ring centrosymmetric metallacycle. The cytotoxicity of the complex was evaluated against the triple-negative human breast cancer cells MDA-MB-231. In order to understand the mechanism of the cytotoxic behavior, a variety of assays, including Annexin V-FITC/Propidium iodide double staining, ROS production, and mitochondrial membrane potential and migration assays were carried out. The results indicated that complex 1 induced cytotoxicity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells.

UR - https://www.scopus.com/pages/publications/85124636119

U2 - 10.1039/d1dt03546k

DO - 10.1039/d1dt03546k

M3 - Article

C2 - 35083998

AN - SCOPUS:85124636119

SN - 1477-9226

VL - 51

SP - 2760

EP - 2769

JO - Dalton Transactions

JF - Dalton Transactions

IS - 7

ER -

A novel cyclic dinuclear gold(i) complex induces anticancer activity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells

Abstract

Bibliographical note

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