A novel biocompatible formate bridged 1D-Cu(ii) coordination polymer induces apoptosis selectively in human lung adenocarcinoma (A549) cells

Copper compounds are promising candidates for next-generation metal anticancer drugs. Therefore, we synthesized and characterized a formate bridged 1D coordination polymer [Cu(L)(HCOO)₂]_n, (L = 2-methoxy-6-methyl-3-((quinolin-8-ylimino)methyl)chroman-4-ol),PCU1, wherein the Cu(ii) center adopts a square pyramidal coordination environment with adjacent Cu⋯Cu distances of 5.28 Å. Primarily,in vitroDNA interaction studies revealed a metallopolymer which possesses high DNA binding propensity and cleaves DNAviathe oxidative pathway. We further analysed its potential on cancerous cells MCF-7, HeLa, A549, and two non-tumorigenic cells HEK293 and HBE. The selective cytotoxicity potential ofPCU1against A549 cells driven us to examine the mechanistic pathways comprehensively by carrying out various assaysviz, cell cycle arrest, Annexin V-FTIC/PI assay, autophagy, intercellular localization, mitochondrial membrane potential ‘MMP’, antiproliferative assay, and gene expression of TGF-β and MMP-2.