TY - JOUR
T1 - A novel biocompatible formate bridged 1D-Cu(ii) coordination polymer induces apoptosis selectively in human lung adenocarcinoma (A549) cells
AU - Usman, Mohammad
AU - Khan, Rais Ahmad
AU - Khan, Mohammad Rashid
AU - Abul Farah, Mohammad
AU - BinSharfan, Ibtisam I.
AU - Alharbi, Walaa
AU - Shaik, Jilani P.
AU - Parine, Narasimha Reddy
AU - Alsalme, Ali
AU - Tabassum, Sartaj
N1 - Publisher Copyright:
© The Royal Society of Chemistry 2021.
PY - 2021/2/14
Y1 - 2021/2/14
N2 - Copper compounds are promising candidates for next-generation metal anticancer drugs. Therefore, we synthesized and characterized a formate bridged 1D coordination polymer [Cu(L)(HCOO)2]n, (L = 2-methoxy-6-methyl-3-((quinolin-8-ylimino)methyl)chroman-4-ol),PCU1, wherein the Cu(ii) center adopts a square pyramidal coordination environment with adjacent Cu⋯Cu distances of 5.28 Å. Primarily,in vitroDNA interaction studies revealed a metallopolymer which possesses high DNA binding propensity and cleaves DNAviathe oxidative pathway. We further analysed its potential on cancerous cells MCF-7, HeLa, A549, and two non-tumorigenic cells HEK293 and HBE. The selective cytotoxicity potential ofPCU1against A549 cells driven us to examine the mechanistic pathways comprehensively by carrying out various assaysviz, cell cycle arrest, Annexin V-FTIC/PI assay, autophagy, intercellular localization, mitochondrial membrane potential ‘MMP’, antiproliferative assay, and gene expression of TGF-β and MMP-2.
AB - Copper compounds are promising candidates for next-generation metal anticancer drugs. Therefore, we synthesized and characterized a formate bridged 1D coordination polymer [Cu(L)(HCOO)2]n, (L = 2-methoxy-6-methyl-3-((quinolin-8-ylimino)methyl)chroman-4-ol),PCU1, wherein the Cu(ii) center adopts a square pyramidal coordination environment with adjacent Cu⋯Cu distances of 5.28 Å. Primarily,in vitroDNA interaction studies revealed a metallopolymer which possesses high DNA binding propensity and cleaves DNAviathe oxidative pathway. We further analysed its potential on cancerous cells MCF-7, HeLa, A549, and two non-tumorigenic cells HEK293 and HBE. The selective cytotoxicity potential ofPCU1against A549 cells driven us to examine the mechanistic pathways comprehensively by carrying out various assaysviz, cell cycle arrest, Annexin V-FTIC/PI assay, autophagy, intercellular localization, mitochondrial membrane potential ‘MMP’, antiproliferative assay, and gene expression of TGF-β and MMP-2.
UR - https://www.scopus.com/pages/publications/85100871393
U2 - 10.1039/d0dt03782f
DO - 10.1039/d0dt03782f
M3 - Article
C2 - 33506238
AN - SCOPUS:85100871393
SN - 1477-9226
VL - 50
SP - 2253
EP - 2267
JO - Dalton Transactions
JF - Dalton Transactions
IS - 6
ER -
