A Highly Selective Enzyme-Free Amperometric Detection of Glucose using Perovskite-Type Lanthanum Cobaltite (LaCoO3)

Elayappan Tamilalagan; Akilarasan Muthumariappan; Tse Wei Chen; Shen Ming Chen; Selvarasu Maheshwaran; Po Jui Huang

doi:10.1149/1945-7111/ac1972

A Highly Selective Enzyme-Free Amperometric Detection of Glucose using Perovskite-Type Lanthanum Cobaltite (LaCoO₃)

Elayappan Tamilalagan
, Akilarasan Muthumariappan
, Tse Wei Chen
, Shen Ming Chen^*
, Selvarasu Maheshwaran
, Po Jui Huang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The disease diabetes mellitus is one of the top-ten causes of death in the world, claiming nearly 1.6 million people per year. Therefore, diagnosis and the monitoring of blood glucose levels are becoming a great concern. Herein, we report a perovskite-type lanthanum cobaltite (LaCoO3) modified electrode as an enzyme-free glucose sensor. The morphological analysis of prepared LaCoO3 was characterized through field emission scanning electron microscopy and transmission electron microscope. The chemical composition and formation of LaCoO3 were analyzed through X-ray diffraction and Raman spectroscopy. In addition, the glucose-sensing property of LaCoO3 was measured using cyclic voltammetry and amperometric-it. In addition, the LaCoO3 modified glass carbon electrode (LaCoO3/GCE) shows an excellent electrochemical activity toward the oxidation of glucose in an alkaline medium (0.1 M NaOH; pH ∼ 13). As a result, the prepared sensor exhibits a wider linear range of 10 nM to 407.2 μM and a very low detection limit of 1.6 nM towards glucose sensing. Finally, the prepared sensor was tested with real samples of human blood and urine and exhibited good found and recoveries values.

Original language	English
Article number	086501
Journal	Journal of the Electrochemical Society
Volume	168
Issue number	8
DOIs	https://doi.org/10.1149/1945-7111/ac1972
State	Published - Aug 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 The Electrochemical Society ("ECS"). Published on behalf of ECS by IOP Publishing Limited.

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Renewable Energy, Sustainability and the Environment
Condensed Matter Physics
Surfaces, Coatings and Films
Electrochemistry
Materials Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1149/1945-7111/ac1972

Cite this

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title = "A Highly Selective Enzyme-Free Amperometric Detection of Glucose using Perovskite-Type Lanthanum Cobaltite (LaCoO3)",

abstract = "The disease diabetes mellitus is one of the top-ten causes of death in the world, claiming nearly 1.6 million people per year. Therefore, diagnosis and the monitoring of blood glucose levels are becoming a great concern. Herein, we report a perovskite-type lanthanum cobaltite (LaCoO3) modified electrode as an enzyme-free glucose sensor. The morphological analysis of prepared LaCoO3 was characterized through field emission scanning electron microscopy and transmission electron microscope. The chemical composition and formation of LaCoO3 were analyzed through X-ray diffraction and Raman spectroscopy. In addition, the glucose-sensing property of LaCoO3 was measured using cyclic voltammetry and amperometric-it. In addition, the LaCoO3 modified glass carbon electrode (LaCoO3/GCE) shows an excellent electrochemical activity toward the oxidation of glucose in an alkaline medium (0.1 M NaOH; pH ∼ 13). As a result, the prepared sensor exhibits a wider linear range of 10 nM to 407.2 μM and a very low detection limit of 1.6 nM towards glucose sensing. Finally, the prepared sensor was tested with real samples of human blood and urine and exhibited good found and recoveries values.",

author = "Elayappan Tamilalagan and Akilarasan Muthumariappan and Chen, \{Tse Wei\} and Chen, \{Shen Ming\} and Selvarasu Maheshwaran and Huang, \{Po Jui\}",

note = "Publisher Copyright: {\textcopyright} 2021 The Electrochemical Society ({"}ECS{"}). Published on behalf of ECS by IOP Publishing Limited.",

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AU - Tamilalagan, Elayappan

AU - Muthumariappan, Akilarasan

AU - Chen, Tse Wei

AU - Chen, Shen Ming

AU - Maheshwaran, Selvarasu

AU - Huang, Po Jui

PY - 2021/8

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N2 - The disease diabetes mellitus is one of the top-ten causes of death in the world, claiming nearly 1.6 million people per year. Therefore, diagnosis and the monitoring of blood glucose levels are becoming a great concern. Herein, we report a perovskite-type lanthanum cobaltite (LaCoO3) modified electrode as an enzyme-free glucose sensor. The morphological analysis of prepared LaCoO3 was characterized through field emission scanning electron microscopy and transmission electron microscope. The chemical composition and formation of LaCoO3 were analyzed through X-ray diffraction and Raman spectroscopy. In addition, the glucose-sensing property of LaCoO3 was measured using cyclic voltammetry and amperometric-it. In addition, the LaCoO3 modified glass carbon electrode (LaCoO3/GCE) shows an excellent electrochemical activity toward the oxidation of glucose in an alkaline medium (0.1 M NaOH; pH ∼ 13). As a result, the prepared sensor exhibits a wider linear range of 10 nM to 407.2 μM and a very low detection limit of 1.6 nM towards glucose sensing. Finally, the prepared sensor was tested with real samples of human blood and urine and exhibited good found and recoveries values.

AB - The disease diabetes mellitus is one of the top-ten causes of death in the world, claiming nearly 1.6 million people per year. Therefore, diagnosis and the monitoring of blood glucose levels are becoming a great concern. Herein, we report a perovskite-type lanthanum cobaltite (LaCoO3) modified electrode as an enzyme-free glucose sensor. The morphological analysis of prepared LaCoO3 was characterized through field emission scanning electron microscopy and transmission electron microscope. The chemical composition and formation of LaCoO3 were analyzed through X-ray diffraction and Raman spectroscopy. In addition, the glucose-sensing property of LaCoO3 was measured using cyclic voltammetry and amperometric-it. In addition, the LaCoO3 modified glass carbon electrode (LaCoO3/GCE) shows an excellent electrochemical activity toward the oxidation of glucose in an alkaline medium (0.1 M NaOH; pH ∼ 13). As a result, the prepared sensor exhibits a wider linear range of 10 nM to 407.2 μM and a very low detection limit of 1.6 nM towards glucose sensing. Finally, the prepared sensor was tested with real samples of human blood and urine and exhibited good found and recoveries values.

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