A correlation of conductivity medium and bioparticle viability on dielectrophoresis-based biomedical applications

Revathy Deivasigamani, Nur Nasyifa Mohd Maidin, Nur Shahira Abdul Nasir, Abdullah Abdulhameed, Aminuddin Bin Ahmad Kayani, Mohd Ambri Mohamed, Muhamad Ramdzan Buyong*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Dielectrophoresis (DEP) bioparticle research has progressed from micro to nano levels. It has proven to be a promising and powerful cell manipulation method with an accurate, quick, inexpensive, and label-free technique for therapeutic purposes. DEP, an electrokinetic phenomenon, induces particle movement as a result of polarization effects in a nonuniform electrical field. This review focuses on current research in the biomedical field that demonstrates a practical approach to DEP in terms of cell separation, trapping, discrimination, and enrichment under the influence of the conductive medium in correlation with bioparticle viability. The current review aims to provide readers with an in-depth knowledge of the fundamental theory and principles of the DEP technique, which is influenced by conductive medium and to identify and demonstrate the biomedical application areas. The high conductivity of physiological fluids presents obstacles and opportunities, followed by bioparticle viability in an electric field elaborated in detail. Finally, the drawbacks of DEP-based systems and the outlook for the future are addressed. This article will aid in advancing technology by bridging the gap between bioscience and engineering. We hope the insights presented in this review will improve cell suspension medium and promote DEP-viable bioparticle manipulation for health-care diagnostics and therapeutics.

Original languageEnglish
Pages (from-to)573-620
Number of pages48
Issue number5-6
StatePublished - Mar 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 Wiley-VCH GmbH.


  • biomedical application
  • cell manipulation
  • conductive medium
  • dielectrophoresis
  • low electrically conductive buffer

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry


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