A convenient palladium-catalyzed carbonylative synthesis of 4(3H)-quinazolinones from 2-bromoformanilides and organo nitros with Mo(CO) 6 as a multiple promoter

Lin He; Muhammad Sharif; Helfried Neumann; Matthias Beller; Xiao Feng Wu

doi:10.1039/c4gc00801d

A convenient palladium-catalyzed carbonylative synthesis of 4(3H)-quinazolinones from 2-bromoformanilides and organo nitros with Mo(CO) ₆ as a multiple promoter

Lin He
, Muhammad Sharif
, Helfried Neumann
, Matthias Beller
, Xiao Feng Wu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

A novel and convenient procedure for the synthesis of quinazolinones has been developed. Using 2-bromoformanilides and organo nitros as substrates and Mo(CO)₆ as a multiple promoter, the desired products were isolated in moderate to excellent yields in the presence of a palladium catalyst. Here, Mo(CO)₆ was not only a CO source, but also a nitro compound reducing reagent and a cyclization promoter. This journal is

Original language	English
Pages (from-to)	3763-3767
Number of pages	5
Journal	Green Chemistry
Volume	16
Issue number	8
DOIs	https://doi.org/10.1039/c4gc00801d
State	Published - Aug 2014
Externally published	Yes

ASJC Scopus subject areas

Environmental Chemistry
Pollution

Access to Document

10.1039/c4gc00801d

Cite this

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title = "A convenient palladium-catalyzed carbonylative synthesis of 4(3H)-quinazolinones from 2-bromoformanilides and organo nitros with Mo(CO) 6 as a multiple promoter",

abstract = "A novel and convenient procedure for the synthesis of quinazolinones has been developed. Using 2-bromoformanilides and organo nitros as substrates and Mo(CO)6 as a multiple promoter, the desired products were isolated in moderate to excellent yields in the presence of a palladium catalyst. Here, Mo(CO)6 was not only a CO source, but also a nitro compound reducing reagent and a cyclization promoter. This journal is",

author = "Lin He and Muhammad Sharif and Helfried Neumann and Matthias Beller and Wu, \{Xiao Feng\}",

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volume = "16",

pages = "3763--3767",

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AU - He, Lin

AU - Sharif, Muhammad

AU - Neumann, Helfried

AU - Beller, Matthias

AU - Wu, Xiao Feng

PY - 2014/8

Y1 - 2014/8

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AB - A novel and convenient procedure for the synthesis of quinazolinones has been developed. Using 2-bromoformanilides and organo nitros as substrates and Mo(CO)6 as a multiple promoter, the desired products were isolated in moderate to excellent yields in the presence of a palladium catalyst. Here, Mo(CO)6 was not only a CO source, but also a nitro compound reducing reagent and a cyclization promoter. This journal is

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DO - 10.1039/c4gc00801d

M3 - Article

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