A comprehensive review of portable syringe systems using micropipette-based extraction techniques for metal analysis

The release of harmful compounds, particularly dangerous metal ions, into the environment has drawn deep concern from the scientific community. Therefore, it has become common in research to evaluate and quantify the harmful concentrations in the presence of these metal ions in several real samples (food, water, and biological samples). To increase sensitivity and lessen the impact of the matrix, sample pretreatment is a helpful strategy to implement before analysis. The limitations of conventional methods have been recently significantly reduced by developing new analytical approaches such as microextraction techniques. The miniaturization of conventional solid-phase extraction (SPE) led to solid-phase microextraction (SPME), drastically reducing both adsorbent use and extraction phase volume. SPME is defined in the present context as a modified extraction technique that employs a portable syringe system attached to micropipette tips. The SPME is considered one of the most appropriate sample preparation tools due to its compatibility with different detection techniques for different metal ions. The current review focuses on SPME based on a portable syringe (attaches to a micropipette tip) system because it has many advantages over conventional solid-phase extraction. It can be designed very simply in a syringe system, a very small quantity of the sorbent has to be kept in the tip, tube, or inside a syringe as a plug and combined with various analytical instruments. Many researchers have designed their own by using homemade tips packed with a sorbent to increase extraction capability and selectivity. According to the current review, there is a lot of potential for increasing the efficacy and efficiency of metal ion extraction from complicated matrices using portable syringe SPME. Studies have shown that when compared to conventional approaches, it performs better in terms of sensitivity, selectivity, and user-friendliness. Furthermore, its application to a wider range of sample types has been enhanced by the flexibility in constructing unique sorbent tips. Conclusively, the developments in portable syringe SPME have addressed several limitations of conventional techniques, positioning it as a robust and versatile tool for environmental monitoring and analysis of hazardous metal ions.