Anti-Cancer Drug(s) effect on the pro-carcinogenic Alpha-1-Syntrophin.

Cancer is the outcome of misregulation at the level of cell signal transduction. Cancer proliferation is coordinately regulated by different proteins. Some of these proteins are anchoring proteins which are located on the just innerface of cytoplasmic membrane. Alpha 1 syntrophin is one such protein attached to dystroglycan complex and also binds to cytoskeletal structures. We have previously shown (Bhat, H.F, et al. 2011) that SNTA1 is significantly increased in solid breast tumors. An increase in SNTA1 expression may be involved in mediating the proliferation and malignancy of the breast cancer cells. Here we aim to look for the effect of the drugs on the role played by SNTA1 in breast cancer cell lines. We would like to study the possible interactions involved with other proteins like RhoGTPase rac1 and cytoskeletal structures like actin and the possible physiological implications like Reactive oxygen species production, Cell proliferation and migration in presence of drugs.