An efficient palladium-catalyzed carbonylative synthesis of pharmaceutically important quinazolinones and related compounds using CO surrogates as carbonyl source

Sustainable developments in our society has been recognized as a corporate knowledge. In the facet of organic synthesis, the advancements of green reactions, with great atom efficacy, high selectivity, free from hazardous reagents and the use of environment friendly solvents as medium, are the main objectives.[1] From the oxidation reactions point of view, the developments of selective and suitable processes are still challenging.[2] Substituted quinazolinones are one of the important core structures encompassing interesting biological activities. The strategies for efficient, chemoselective and regioselective synthesis of these building blocks are, therefore, highly desired. We are particularly interested in the synthesis of quinazolinones, benzoxazinones and aminobezoxazinone compounds as they have the potential of outstanding activities as anti-cancer, anti-inflamator and Anti-bacterial.[2h, 2i, 2j] In a scenario where the classical methods reported for the synthesis of quinazolinones, benzoxazinones as well as aminobenzoxazinones, compounds are complex and limited only to a few methodologies.